Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action

WSD Tan, W Liao, S Zhou, WSF Wong - Biochemical pharmacology, 2017 - Elsevier
Andrographis paniculata has long been part of the traditional herbal medicine system in
Asia and in Scandinavia. Andrographolide was isolated as a major bioactive constituent of …

[HTML][HTML] Andrographolide, a natural anti-inflammatory agent: An Update

X Li, W Yuan, J Wu, J Zhen, Q Sun, M Yu - Frontiers in pharmacology, 2022 - frontiersin.org
Botanicals have attracted much attention in the field of anti-inflammatory due to their good
pharmacological activity and efficacy. Andrographis paniculata is a natural plant ingredient …

[HTML][HTML] Andrographolide, an anti-inflammatory multitarget drug: all roads lead to cellular metabolism

RA Burgos, P Alarcón, J Quiroga, C Manosalva… - Molecules, 2020 - mdpi.com
Andrographolide is a labdane diterpene and the main active ingredient isolated from the
herb Andrographis paniculata. Andrographolide possesses diverse biological effects …

Advances in ameliorating inflammatory diseases and cancers by andrographolide: pharmacokinetics, pharmacodynamics, and perspective

J Qu, Q Liu, G You, L Ye, Y Jin, L Kong… - Medicinal Research …, 2022 - Wiley Online Library
Andrographolide, a well‐known natural lactone having a range of pharmacological actions
in traditional Chinese medicine. It has long been used to cure a variety of ailments. In this …

Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide

T Jayakumar, CY Hsieh, JJ Lee… - … and Alternative Medicine, 2013 - Wiley Online Library
Andrographis paniculata (Burm. F) Nees, generally known as “king of bitters,” is an
herbaceous plant in the family Acanthaceae. In China, India, Thailand, and Malaysia, this …

[HTML][HTML] An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide

M Low, CS Khoo, G Münch, S Govindaraghavan… - … and Alternative Medicine, 2015 - Springer
Background The anti-inflammatory activity of Andrographis paniculata (Acanthaceae), a
traditional medicine widely used in Asia, is commonly attributed to andrographolide, its main …

Inhibition of TNF-α-Induced Inflammation by andrographolide via down-regulation of the PI3K/Akt signaling pathway

HW Chen, AH Lin, HC Chu, CC Li… - Journal of natural …, 2011 - ACS Publications
Andrographolide (1), an active constituent of Andrographis paniculata, decreased tumor
necrosis factor-α (TNF-α)-induced intercellular adhesion molecule-1 (ICAM-1) expression …

Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer

JCW Lim, TK Chan, DSW Ng… - Clinical and …, 2012 - Wiley Online Library
Andrographis paniculata (Burm. f) Nees, commonly known as 'king of bitters', is a
herbaceous plant belonging to the Family Acanthaceae. It has been widely used for …

AP‐1/IRF‐3 Targeted Anti‐Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata

T Shen, WS Yang, YS Yi, GH Sung… - Evidence‐Based …, 2013 - Wiley Online Library
Andrographolide (AG) is an abundant component of plants of the genus Andrographis and
has a number of beneficial properties including neuroprotective, anticancer, anti …

Andrographolide Benefits Rheumatoid Arthritis via Inhibiting MAPK Pathways

Z Li, J Tan, L Wang, Q Li - Inflammation, 2017 - Springer
Andrographolide (AD) is the main compound distributed in medicinal herb Andrographis
paniculata and exhibits anti-inflammatory activity. AD has been used for the treatment of …