Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination
and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so …

Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated autoimmune disease
of the central nervous system that is widely used as an animal model of multiple sclerosis …

Molecular interventions that limit pathogenic CNS inflammation are used to treat
autoimmune conditions such as multiple sclerosis (MS). Remarkably, IL-1β–knockout mice …

Multiple sclerosis (MS) is an autoimmune disease of the CNS characterized by disruption of
the blood-brain barrier (BBB). This breach in CNS immune privilege allows undeterred …

The chemokine receptor CCR2 plays a vital role for the induction of autoimmunity in the
central nervous system. However, it remains unclear how the pathogenic response is …

Monocytes and macrophages play a pathogenic role in a number of autoimmune
inflammatory diseases. Recent studies in experimental autoimmune encephalomyelitis …

Multiple sclerosis (MS) is a chronic demyelinating disease characterised by immune cell
infiltration resulting in lesions that preferentially affect periventricular areas of the brain …

The movement of lymphocytes from the microvasculature into the central nervous system
(CNS) parenchyma is an essential step in the pathogenesis of a variety of infectious and …

The role of microglia and monocyte-derived macrophages in experimental autoimmune
encephalomyelitis pathogenesis has been controversial. To gain insight into their respective …

Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation,
demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells …