The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

J Machado-Santos, E Saji, AR Tröscher, M Paunovic… - Brain, 2018 - academic.oup.com
Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination
and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so …

Lymphoid chemokines in the diagnosis, monitoring and treatment of inflammatory disease

BM Segal, L Bagaeva - US Patent 7,390,884, 2008 - Google Patents
Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated autoimmune disease
of the central nervous system that is widely used as an animal model of multiple sclerosis …

IL-1β enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells

A Paré, B Mailhot, SA Lévesque… - Proceedings of the …, 2018 - National Acad Sciences
Molecular interventions that limit pathogenic CNS inflammation are used to treat
autoimmune conditions such as multiple sclerosis (MS). Remarkably, IL-1β–knockout mice …

IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune …

EE McCandless, M Budde, JR Lees… - The Journal of …, 2009 - journals.aai.org
Multiple sclerosis (MS) is an autoimmune disease of the CNS characterized by disruption of
the blood-brain barrier (BBB). This breach in CNS immune privilege allows undeterred …

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

A Mildner, M Mack, H Schmidt, W Brück, M Djukic… - Brain, 2009 - academic.oup.com
The chemokine receptor CCR2 plays a vital role for the induction of autoimmunity in the
central nervous system. However, it remains unclear how the pathogenic response is …

Targeting monocyte recruitment in CNS autoimmune disease

L Izikson, RS Klein, AD Luster, HL Weiner - Clinical Immunology, 2002 - Elsevier
Monocytes and macrophages play a pathogenic role in a number of autoimmune
inflammatory diseases. Recent studies in experimental autoimmune encephalomyelitis …

Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

S Rodríguez-Lorenzo, L van Olst… - Elife, 2022 - elifesciences.org
Multiple sclerosis (MS) is a chronic demyelinating disease characterised by immune cell
infiltration resulting in lesions that preferentially affect periventricular areas of the brain …

Regulation of neuroinflammation: the role of CXCL10 in lymphocyte infiltration during autoimmune encephalomyelitis

RS Klein - Journal of cellular biochemistry, 2004 - Wiley Online Library
The movement of lymphocytes from the microvasculature into the central nervous system
(CNS) parenchyma is an essential step in the pathogenesis of a variety of infectious and …

RNA sequencing of microglia and monocyte-derived macrophages from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with …

ND Lewis, JD Hill, KW Juchem… - Journal of …, 2014 - Elsevier
The role of microglia and monocyte-derived macrophages in experimental autoimmune
encephalomyelitis pathogenesis has been controversial. To gain insight into their respective …

[HTML][HTML] Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

E Mills Ko, JH Ma, F Guo, L Miers, E Lee… - Journal of …, 2014 - Springer
Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation,
demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells …