Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …

Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …

Epigenetic reprogramming is a central process during mammalian germline development.
Genome-wide DNA demethylation in primordial germ cells (PGCs) is a prerequisite for the …

Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …

Germ cells, after fate determination as primordial germ cells (PGCs) in early embryos,
undergo various unique changes in epigenetic status during their development, and these …

DNA methylation is a carrier of important regulatory information that undergoes global
reprogramming in the mammalian germ line, including pre-implantation embryos and …

In this review, advances in the understanding of epigenetic reprogramming from fertilization
to the development of primordial germline cells in a mouse and human embryo are …

We recently elucidated the mechanism of human primordial germ cell (hPGC) specification
and resetting of the epigenome for totipotency. The regulators of hPGC specification also …

Epigenetic reprogramming, characterized by loss of cytosine methylation and histone
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are the route to totipotency
and require establishment of a unique epigenome in this lineage. The genetic program for …