We provide here an example of clinical application of functional glycoproteomics for cancer
diagnosis. Sialyl Lewis a and sialyl Lewis x glycotopes, which are the specific ligands for …

CD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion,
signal transduction and cytoskeleton remodelling. It is also one of the most studied …

Glycosylation is a posttranslational modification of proteins playing a major role in cell
signalling, immune recognition, and cell‐cell interaction because of their glycan branches …

CD44 variant isoforms are often upregulated in cancer and associated with increased
aggressive tumor phenotypes. The CD44v9 is one of the major protein splice variant …

In recent years, the measurement of soluble CD44 levels in the circulation of patients with
malignant diseases has been introduced as a new and simple diagnostic tool for the …

It has been suggested that soluble CD44 levels in cancer patient sera may be closely
associated with tumor progression and metastasis. However, to date, there has been limited …

CD44, a family of closely related glycoproteins generated by alternative splicing, as well as
the increased β1, 6‐branching of Asn‐linked oligosaccharides (β1, 6‐branches), have been …

The surface glycoprotein CD44 is widely distributed in different tissues. In contrast to healthy
tissue, tumour samples show a more complex pattern of CD44 expression, indicating a loss …

PURPOSE: Alternative splicing of CD44 and aberrant levels of soluble CD44 (sCD44)
protein in the serum of cancer patients has been correlated to tumor progression and …

While performing a prospective study on sCD44 variant isoforms as tumour markers in
certain malignancies, we detected relevant differences in the control group between non …