DNA methylation is involved in a number of important processes such as maintaining
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …

Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …

In mice, assisted reproductive technologies (ARTs) applied during gametogenesis and
preimplantation development can result in disruption of genomic imprinting. In humans …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

Epigenetic modifications, and particularly DNA methylation, have been studied in many
tissues, both healthy and diseased, and across numerous developmental stages. The …

Embryogenesis is tightly regulated by multiple levels of epigenetic regulation such as DNA
methylation, histone modification, and chromatin remodeling. DNA methylation patterns are …