Role of quinone-mediated generation of hydroxyl radicals in the induction of glutathione S-transferase gene expression

R Pinkus, LM Weiner, V Daniel - Biochemistry, 1995 - ACS Publications
Revised Manuscript Received September 22, 1994® abstract; Induction of glutathione 5-
transferase (GST) Ya gene expression by a variety of chemical agents is mediated by a …

Intracellular Glutathione Levels Regulate Fos/Jun Induction and Activation of Glutathione S-Transferase Gene Expression

S Bergelson, R Pinkus, V Daniel - Cancer Research, 1994 - AACR
Induction of glutathione S-transferase Ya and NAD (P) H: quinone reductase gene
expression by a variety of chemical agents is mediated by regulatory elements, EpRE and …

Regulatory Mechanisms Involved in Activator‐Protein‐1 (AP‐1)‐Mediated Activation of Glutathione‐S‐Transferase Gene Expression by Chemical Agents

E Ainbinder, S Bergelson, R Pinkus… - European journal of …, 1997 - Wiley Online Library
Induction of murine glutathione‐S‐transferase (GST) Ya gene expression by a variety of
chemical agents is mediated by a regulatory element, EpRE, composed of an Ets and two …

Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester …

T Nguyen, TH Rushmore, CB Pickett - Journal of Biological Chemistry, 1994 - Elsevier
Using transfection and gel retardation assays, we have characterized further the antioxidant
response element (ARE) found in the 5'-flanking region of the rat glutathione S-transferase …

Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.

S Bergelson, R Pinkus, V Daniel - Oncogene, 1994 - europepmc.org
A regulatory element, EpRE, was found to be responsible for the induction of mouse
glutathione S-transferase (GST) Ya gene expression by a variety of chemical agents such as …

Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells

MM Shi, A Kugelman, T Iwamoto, L Tian… - Journal of Biological …, 1994 - Elsevier
Glutathione (GSH) is one of the most important physiological antioxidants involved in
detoxification of hydrogen peroxide and lipid hydroperoxide. Previous studies have shown …

Glutathione S-transferases: gene structure and regulation of expression

V Daniel - Critical reviews in biochemistry and molecular biology, 1993 - Taylor & Francis
The current knowledge about the structure of GST genes and the molecular mechanisms
involved in regulation of their expression are reviewed. Information derived from the study of …

Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.

RS Friling, S Bergelson… - Proceedings of the …, 1992 - National Acad Sciences
An electrophile-responsive element (EpRE) in the 5'flanking region of the mouse glutathione
S-transferase Ya subunit gene was recently found to be responsible for the induction of …

Cooperative interaction between Ets and AP-1 transcription factors regulates induction of glutathione S-transferase Ya gene expression

S Bergelson, V Daniel - Biochemical and biophysical research …, 1994 - Elsevier
Induction of mouse glutathione S-transferase (GST) Ya gene expression by a variety of
chemical agents is mediated by a regulatory element, EpRE, composed of an Ets and two …

Control of expression of the human glutathione S-transferase π gene differs from its rat orthologue

KH Dixon, IG Cowell, CL Xia, SE Pemble… - Biochemical and …, 1989 - Elsevier
We have examined regulation of the glutathione S-transferaseπ gene by transient
expression assay, and find that a fragment from 8 to 99 bp upstream of the cap site promotes …