IL-1 beta is the major form of IL-1 produced by mononuclear phagocytes. To evaluate the
possible mechanisms underlying the observation that mature populations of human …

Fresh human alveolar macrophages and blood monocytes were stimulated with LPS and
assessed for their ability to produce and release antigenic IL-1 beta. Using a sensitive and …

To assess the ability of human alveolar macrophages to produce interleukin-1· beta (IL1-
beta), we examined IL1-beta mRNA accumulation in autologous monocytes and alveolar …

Maturation of blood monocytes into macrophages is accompanied by a number of functional
changes including decreased IL-1 beta release in response to LPS. This limitation has …

Interleukin (IL)-8 is a macrophage-derived neutrophil chemotactic factor that plays an
important role in the recruitment of neutrophils to inflammatory loci. Hence, expression of IL …

Cultured human monocytes and tissue macrophages exhibit a marked decrease in LPS-
stimulated IL-1 production. Preincubation of monocytes in 100 U/ml IFN-gamma or in 0.25 …

When rabbit alveolar macrophages were treated with phorbol-12-myristate-13-acetate
(PMA) and lipopolysaccharide (LPS), the synthesis of interleukin-1 (IL-1), as well as tumor …

Human peripheral blood mononuclear cells analyzed immediately after isolation did not
express detectable mRNA for interleukin-1 beta (IL-1 beta). In the strict absence of …

We have previously shown that in mixed cultures of PBL incubation with human rIL-2
induces the rapid expression of IL-1 alpha and IL-1 beta mRNA. Because studies have …

Abstract Interleukin-1 (IL-1) is a cytokine with a wide range of effects on a variety of cell
types. By hybridization with human IL-1 alpha and IL-1 beta cDNA probes, the …