[HTML][HTML] Aging in the context of immunological architecture, function and disease outcomes
AL DiCarlo, R Fuldner, J Kaminski, R Hodes - Trends in immunology, 2009 - cell.com
The aging immune system demonstrates a reduced capacity to mount a robust immune
response (immunosenescence), thereby increasing the susceptibility to various infectious …
response (immunosenescence), thereby increasing the susceptibility to various infectious …
[HTML][HTML] Immunosenescence and human vaccine immune responses
SN Crooke, IG Ovsyannikova, GA Poland… - Immunity & …, 2019 - Springer
The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …
“immunosenescence”—has been generally associated with an increased susceptibility to …
[HTML][HTML] Immune senescence: known knowns and unknown unknowns
T Fulop, RR Montgomery - Current opinion in immunology, 2014 - ncbi.nlm.nih.gov
The elderly have increased susceptibility to infectious diseases and a decreased response
to vaccination. A large body of data suggests this is a result of age-related functional …
to vaccination. A large body of data suggests this is a result of age-related functional …
[HTML][HTML] Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging
G Del Giudice, JJ Goronzy… - npj Aging and …, 2017 - nature.com
The progressive increase of the aged population worldwide mandates new strategies to
ensure sustained health and well-being with age. The development of better and/or new …
ensure sustained health and well-being with age. The development of better and/or new …
[HTML][HTML] Age-associated declines in immune system development and function: causes, consequences, and reversal
K Dorshkind, S Swain - Current opinion in immunology, 2009 - ncbi.nlm.nih.gov
Understanding why we age and how that process can be delayed or reversed are topics that
have engaged both researchers and the general public [1]. From a scientific perspective …
have engaged both researchers and the general public [1]. From a scientific perspective …
Translational research in immune senescence: assessing the relevance of current models
KP High, AN Akbar, J Nikolich-Zugich - Seminars in immunology, 2012 - Elsevier
Advancing age is accompanied by profound changes in immune function; some are induced
by the loss of critical niches that support development of naïve cells (eg thymic involution) …
by the loss of critical niches that support development of naïve cells (eg thymic involution) …
Age-related decline in immunity: implications for vaccine responsiveness
R Kumar, EA Burns - Expert review of vaccines, 2008 - Taylor & Francis
Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …
leading to progressive deterioration in both innate and adaptive immunity. These changes …
Understanding immunosenescence and its impact on vaccination of older adults
JC Allen, FR Toapanta, W Chen, SM Tennant - Vaccine, 2020 - Elsevier
Older adults are more susceptible to viral and bacterial infection, and experience higher
incidence and severity of infectious diseases. Although vaccination is the most logical …
incidence and severity of infectious diseases. Although vaccination is the most logical …
Advancing age and immune cell dysfunction: is it reversible or not?
S Suvas - Expert Opinion on Biological Therapy, 2008 - Taylor & Francis
Background: Decline in immune function with advancing age is a hallmark of aging. As a
result, infectious diseases cause more morbidity and mortality to the elderly. These age …
result, infectious diseases cause more morbidity and mortality to the elderly. These age …
The aging of the immune system
D Weiskopf, B Weinberger… - Transplant …, 2009 - Wiley Online Library
An age‐related decline in immune functions, referred to as immunosenescence, is partially
responsible for the increased prevalence and severity of infectious diseases, and the low …
responsible for the increased prevalence and severity of infectious diseases, and the low …