In search for innovative therapeutic agents for children neuroblastoma, the oxygen therapy
could be considered an alternative anti‐tumoral treatment. Given the physiochemical …

Purpose We evaluated in vitro the role of CO 2-induced oxidative stress on the expression of
proteins involved in cell-cycle regulation of neuroblastoma cells. Methods SH-SY5Y cells …

In adults, glioma is the most commonly occurring and invasive brain tumour. For malignant
gliomas, the current advanced chemotherapy includes TMZ (temozolomide). However, a …

Cyclin D1 and cyclin E1, as vital regulatory factors of G1-S phase cell cycle progression, are
frequently constitutive expressed and associated with pathogenesis and tumorigenesis in …

Cell cycle regulators such as cyclin-dependent kinases (Cdks) and their inhibitors (Ckis)
have been reported to be involved in neuronal cell death (NCD) induced by a variety of …

Neuroblastoma is the most common extra-cranial solid tumor in children. Despite advances
in the treatment of childhood cancer, outcomes for children with advanced-stage …

In our laboratory, a novel therapeutic probe, T11TS, a membrane glycoprotein, was isolated
which had antineoplastic activity against experimental glioma. Development of a novel …

Medulloblastoma is one of the most common malignant brain tumor types in children, with
an overall survival of 70%. Mortality is associated with metastatic relapsed tumors. Rho …

Olomoucine and Roscovitine are two ATP-competing compounds described as specific
inhibitors of cyclin-dependent kinases (CDK). Both drugs showed to induce apoptosis in SH …

Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer
cells to chemotherapy and radiation is inhibited by the presence of antioxidants, such as …