Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in
adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression …

Increasing evidence implicates the c-Jun NH2-terminal kinase (JNK) pathway in the
regulation of apoptosis in neurodegenerative diseases. In this study, we examined the …

To defend against the potential damages induced by reactive oxygen species, proliferating
cells enter a transient cell cycle arrest. We treated mouse fibroblasts with H 2 O 2 and found …

The role of regulators controlling the G1/S transition of the cell cycle was analyzed during
neuronal apoptosis in post-mitotic cerebellar granule cells in an attempt to identify common …

CDK4/6 inhibitors are remarkable anti-cancer drugs that can arrest tumor cells in G1 and
induce their senescence while causing only relatively mild toxicities in healthy tissues. How …

Neuroblastoma is the most frequent, extracranial solid tumor in children with still poor
prognosis in stage IV disease. In this study, we analyzed FOXO3-phosphorylation and …

The regulation of D-type cyclin-dependent kinase activity is critical for neuronal
differentiation and apoptosis. We recently showed that cyclin D1 is sequestered in the …

BACKGROUND: Neuroblastoma (NB) is one of the most common extracranial tumors in
children. The chemotherapeutic doxorubicin (Dox) remains a mainstay for treatment …

We have previously shown that compound-7g inhibits colorectal cancer cell proliferation and
survival by inducing cell cycle arrest and PI3K/AKT/mTOR pathway blockage. However …

Hypoxia is associated with the increased malignancy of a broad range of solid tumours.
While very severe hypoxia has been widely shown to induce cell cycle arrest, the impact of …