Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2
Emerging evidence suggests that host glycans influence severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. Here, we reveal that the receptor-binding domain …
coronavirus 2 (SARS-CoV-2) infection. Here, we reveal that the receptor-binding domain …
Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2
W Saso, M Yamasaki, S Nakakita, S Fukushi… - PLoS …, 2022 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been transmitted
across all over the world, in contrast to the limited epidemic of genetically-and virologically …
across all over the world, in contrast to the limited epidemic of genetically-and virologically …
[HTML][HTML] SARS-CoV-2 spike protein interacts with multiple innate immune receptors
The spike (S) glycoprotein in the envelope of SARS-CoV-2 is densely glycosylated but the
functions of its glycosylation are unknown. Here we demonstrate that S is recognized in a …
functions of its glycosylation are unknown. Here we demonstrate that S is recognized in a …
[HTML][HTML] Subtle influence of ACE2 glycan processing on SARS-CoV-2 recognition
The severity of SARS-CoV-2 infection is highly variable and yet the molecular basis for this
effect remains elusive. One potential contribution are differences in the glycosylation of …
effect remains elusive. One potential contribution are differences in the glycosylation of …
The role of cell surface sialic acids for SARS-CoV-2 infection
XL Sun - Glycobiology, 2021 - academic.oup.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a new virus that has
higher contagious capacity than any other previous human coronaviruses (HCoVs) and …
higher contagious capacity than any other previous human coronaviruses (HCoVs) and …
Sialylated glycan bindings from SARS-CoV-2 spike protein to blood and endothelial cells govern the severe morbidities of COVID-19
DE Scheim, P Vottero, AD Santin, AG Hirsh - International journal of …, 2023 - mdpi.com
Consistent with well-established biochemical properties of coronaviruses, sialylated glycan
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …
attachments between SARS-CoV-2 spike protein (SP) and host cells are key to the virus's …
Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection
A Casas-Sanchez, A Romero-Ramirez, E Hargreaves… - MBio, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) extensively N-glycosylates
its spike proteins, which are necessary for host cell invasion and the target of both vaccines …
its spike proteins, which are necessary for host cell invasion and the target of both vaccines …
Inhibition of SARS-CoV-2 viral entry upon blocking N-and O-glycan elaboration
The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary
receptor ACE2 are extensively glycosylated. The impact of this post-translational …
receptor ACE2 are extensively glycosylated. The impact of this post-translational …
Glycosylation is a key in SARS-CoV-2 infection
CA Reis, R Tauber, V Blanchard - Journal of Molecular Medicine, 2021 - Springer
SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current
pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and …
pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and …
Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection
The recent emergence of highly transmissible SARS-CoV-2 variants illustrates the urgent
need to better understand the molecular details of the virus binding to its host cell and to …
need to better understand the molecular details of the virus binding to its host cell and to …