Supercritical fluids for pharmaceutical particle engineering: Methods, basic fundamentals and modelling

A Tabernero, EMM del Valle, MA Galán - Chemical Engineering and …, 2012 - Elsevier
The interest of the use of supercritical fluids, especially supercritical CO2, for particle
engineering over the last years has received attention from the pharmaceutical industry …

Solid-state chemistry and particle engineering with supercritical fluids in pharmaceutics

I Pasquali, R Bettini, F Giordano - European journal of pharmaceutical …, 2006 - Elsevier
The present commentary aims to review the modern and innovative strategies in particle
engineering by the supercritical fluid technologies and it is principally concerned with the …

Particle generation for pharmaceutical applications using supercritical fluid technology

J Fages, H Lochard, JJ Letourneau, M Sauceau… - Powder Technology, 2004 - Elsevier
In the pharmaceutical industry, an even greater number of products are in the form of
particulate solids. Their formation, formulation and the control of their user properties are still …

Microencapsulation and nanoencapsulation using supercritical fluid (SCF) techniques

SH Soh, LY Lee - Pharmaceutics, 2019 - mdpi.com
The unique properties of supercritical fluids, in particular supercritical carbon dioxide (CO2),
provide numerous opportunities for the development of processes for pharmaceutical …

Current situation and perspectives in drug formulation by using supercritical fluid technology

E Badens, Y Masmoudi, A Mouahid… - The Journal of …, 2018 - Elsevier
Supercritical fluid (SCF) technology has been applied to drug product development over the
last thirty years and drug particle generation using SCFs appears to be an efficient way to …

Particle design using supercritical fluids: literature and patent survey

J Jung, M Perrut - The Journal of supercritical fluids, 2001 - Elsevier
As particle design is presently a major development of supercritical fluids applications,
mainly in the pharmaceutical, nutraceutical, cosmetic and specialty chemistry industries …

Supercritical fluid formulation: process choice and scale-up

M Perrut, JY Clavier - Industrial & engineering chemistry research, 2003 - ACS Publications
Very important R&D efforts are presently dedicated to applications of supercritical fluids
(SCFs) in the pharmaceutical industry, especially for formulation and particle design, but few …

Are supercritical fluids solvents for the future?

Ž Knez, M Pantić, D Cör, Z Novak, MK Hrnčič - Chemical Engineering and …, 2019 - Elsevier
High pressure technologies involving sub and supercritical fluids offer the possibility to
obtain new products with special characteristics or to design new processes which are …

Supercritical fluid technologies: an innovative approach for manipulating the solid-state of pharmaceuticals

I Pasquali, R Bettini, F Giordano - Advanced Drug Delivery Reviews, 2008 - Elsevier
Solid-state, crystallographic purity and careful monitoring of the polymorphism of drugs and
excipients are currently an integral part of the development of modern drug delivery systems …

Particle formation and product formulation using supercritical fluids

Ž Knez, M Knez Hrnčič, M Škerget - Annual review of chemical …, 2015 - annualreviews.org
Traditional methods for solids processing involve either high temperatures, necessary for
melting or viscosity reduction, or hazardous organic solvents. Owing to the negative impact …