Clinical immunity to malaria is associated with the acquisition of IgG specific for members of
the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally …

In pregnancy, parity-dependent immunity is observed in response to placental infection with
Plasmodium falciparum. Antibodies recognize the surface antigen, VAR2CSA, expressed on …

Plasmodium falciparum parasites causing placental malaria express the VAR2CSA type of
the clonally variant antigen family erythrocyte membrane protein 1 (PfEMP1). This enables …

Background Pregnant women are infected by Plasmodium falciparum with novel antigenic
phenotypes that adhere to chondroitin sulfate A (CSA) and other receptors in the placenta …

There is substantial immuno-epidemiological evidence that the parasite-encoded, so-called
variant surface antigens (VSAs) such as PfEMP1 on the surface of infected erythrocytes (IEs) …

During pregnancy, specific variants of Plasmodium falciparum-infected erythrocytes (IEs)
can accumulate in the placenta through adhesion to chondroitin sulfate A (CSA) mediated …

Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …

Abstract Background In pregnancy, Plasmodium falciparum parasites express the surface
antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A …

In areas of high Plasmodium falciparum transmission, immunity to malaria is acquired during
childhood, so that adults in general are clinically immune. One exception is that first-time …

Variant surface antigens (VSA) on the surface of Plasmodium falciparum-infected red blood
cells play a major role in the pathogenesis of malaria and are key targets for acquired …