Bone mesenchymal stem cells are recruited via CXCL8‐CXCR2 and promote EMT through TGF‐β signal pathways in oral squamous carcinoma

L Meng, Y Zhao, W Bu, X Li, X Liu, D Zhou… - Cell …, 2020 - Wiley Online Library
Objectives Bone mesenchymal stem cells (BMSCs) play critical roles in tumour
microenvironment. However, molecular mechanisms of how BMSCs to be recruited and …

Human bone marrow mesenchymal stem cells induce collagen production and tongue cancer invasion

S Salo, C Bitu, K Merkku, P Nyberg, IO Bello… - PLoS …, 2013 - journals.plos.org
Tumor microenvironment (TME) is an active player in carcinogenesis and changes in its
composition modify cancer growth. Carcinoma-associated fibroblasts, bone marrow-derived …

Bone marrow mesenchymal stem cells promote osteosarcoma cell proliferation and invasion

FX Yu, WJ Hu, B He, YH Zheng, QY Zhang… - World journal of surgical …, 2015 - Springer
Background Bone marrow-derived stem cells (BMSCs) are locally adjacent to the tumor
tissues and may interact with tumor cells directly. The purpose of this study was to explore …

The effects of mesenchymal stem cells on oral cancer and possible therapy regime

T Yang, S Tang, S Peng, G Ding - Frontiers in genetics, 2022 - frontiersin.org
Mesenchymal stem cells (MSCs) are characterized by self-renewal, rapid proliferation,
multipotent differentiation, and low immunogenicity. In addition, the tropism of MSCs towards …

CXCL12/CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC

X Li, W Bu, L Meng, X Liu, S Wang, L Jiang… - Experimental cell …, 2019 - Elsevier
Abstract Tumor-associated macrophage (TAM), a crucial component of immune cell
infiltrated in tumor microenvironment, is associated with progression of oral squamous cell …

The effect of mesenchymal stem cells on chemotaxis of osteoclast precursor cells

K Sumi, T Abe, R Kunimatsu, N Oki, Y Tsuka… - Journal of Oral …, 2018 - jstage.jst.go.jp
Regeneration of tissue, including bone, using mesenchymal stem cells (MSCs) has been
progressing rapidly. Regeneration of bone requires the presence of an appropriate …

Cancer-associated stromal cells promote the contribution of mmp2-positive bone marrow-derived cells to oral squamous cell carcinoma invasion

MW Oo, H Kawai, K Takabatake, Q Shan, HS Eain… - Cancers, 2021 - mdpi.com
Simple Summary Based on its invasiveness, oral squamous cell carcinoma (OSCC) shows
two different subtypes: less-invasive verrucous squamous carcinoma (VSCC) or highly …

[HTML][HTML] Osteoblasts are induced into cancer-associated osteoblasts to promote tumor progression in head and neck squamous cell carcinoma

Y Chen, X Zheng, W Shi, C Lu, Y Qiu, L Lin - Biochimica et Biophysica Acta …, 2024 - Elsevier
Bone invasion by head and neck squamous cell carcinoma (HNSCC) significantly impacts
tumor staging, treatment choice, prognosis, and quality of life. While HNSCC is known to …

BMSC–HNC Interaction: Exploring Effects on Bone Integrity and Head and Neck Cancer Progression

J Eichberger, D Froschhammer, D Schulz… - International Journal of …, 2023 - mdpi.com
In recent research, the tumor microenvironment has been shown to attract mesenchymal
stromal cells (MSCs), which is of particular interest due to its implications for cancer …

Mesenchymal stem cells derived from normal gingival tissue inhibit the proliferation of oral cancer cells in vitro and in vivo

X Ji, Z Zhang, Y Han, J Song, X Xu… - International …, 2016 - spandidos-publications.com
The interplay between tumor cells and mesenchymal stem cells (MSCs) within tumor
microenvironment plays a significant role in tumor development, and thus might be exploited …