Rationale: The second heart field (SHF) contains progenitors of all heart chambers,
excluding the left ventricle. The SHF is patterned, and the anterior region is known to be …

Publisher Summary This chapter discusses the findings that preceded and led to the
identification of this progenitor cell population, and different molecular and genetic …

The second heart field (SHF) is indicated to contribute to the embryonic heart development.
However, less knowledge is available about SHF development of human embryo due to the …

The right ventricle and outflow tract of the developing heart are derived from mesodermal
progenitor cells from the second heart field (SHF). SHF cells have been characterized by …

Elongation of the vertebrate heart occurs by progressive addition of second heart field (SHF)
cardiac progenitor cells from pharyngeal mesoderm to the poles of the heart tube. The …

The vertebrate heart tube forms from epithelial progenitor cells in the early embryo and
subsequently elongates by progressive addition of second heart field (SHF) progenitor cells …

Splanchnic mesoderm in the region described as the second heart field (SHF) is marked by
Islet1 expression in the mouse embryo. The anterior part of this region expresses a number …

At the end of the first week of mouse gestation, cardiomyocyte differentiation initiates in the
cardiac crescent to give rise to the linear heart tube. The heart tube subsequently elongates …

Heart formation relies on two sources of cardiomyocytes: the first heart field (FHF), which
gives rise to the linear heart tube, and the second heart field (SHF), which gives rise to the …

Although de la Cruz and colleagues showed as early as 1977 that the outflow tract was
added after the heart tube formed, the source of these secondarily added cells was not …