Mammalian heart development involves complex morphogenetic events which lead to the
formation of fully separated left and right atrial and ventricular chambers from a tubular heart …

Background The small GTP ase Rac1 regulates diverse cellular functions, including both
apicobasal and planar cell polarity pathways; however, its role in cardiac outflow tract (OFT) …

Many vertebrate organs are derived from monolayered epithelia that undergo
morphogenesis to acquire their shape. Whereas asymmetric left/right gene expression …

Heart malformations are common congenital defects in humans. Many congenital heart
defects involve anomalies in cardiac septation or valve development, and understanding the …

Background Rapid growth of the embryonic heart occurs by addition of progenitor cells of
the second heart field to the poles of the elongating heart tube. Failure or perturbation of this …

In 2001, three research groups described a previously unrecognized population of
progenitor cells in pharyngeal mesoderm that gives rise to myocardium at the arterial pole of …

Cardiac outflow tract (OFT) septation is crucial to the formation of the aortic and pulmonary
arteries. Defects in the formation of the OFT can result in serious congenital heart defects …

The vertebrate heart is formed from diverse embryonic territories, including the first and
second heart fields. The second heart field (SHF) gives rise to the right ventricle and outflow …

Congenital heart defects are the most common birth defects in humans, and those that affect
the proper alignment of the outflow tracts and septation of the ventricles are a highly …

The primary heart tube is an endocardial tube, ensheathed by myocardial cells, that
develops from bilateral primary heart fields located in the lateral plate mesoderm. Earlier …