Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …

Capsaicin produces pain by selectively activating polymodal nociceptive neurons. This
involves a membrane depolarization and the opening of a unique, cation-selective, ion …

1 Capsazepine has recently been described as a competitive capsaicin antagonist. We have
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin …

Capsaicin acts specifically on a subset of primary afferent sensory neurons to open cation-
selective ion channels, probably by interacting directly with a membrane receptor-ion …

Capsaicin was tested on peripheral fibres in vitro to determine whether evoked
depolarization or desensitization were likely to explain the antinociception observed after …

This study was designed to investigate the antinociceptive activity of capsaicin in acute and
persistent nocifensor behavioural models and to determine whether this was mediated via a …

Capsaicin and its analog, dihydrocapsaicin, produced chemogenic and thermal
antinociception and depletion of substance P from the dorsal spinal cord and dorsal root …

In the late fifties and sixties Jancso published a series of papers on 'the peculiar
pharmacological effect of capsaicin Capsaicin or 8-methyl-N-vanillyi-6-nonenamide is the …

Recent work on the excitatory action of capsaicin on somatic and visceral afferent neurones
shows that depolarization is selective for C-fibre polymodal nociceptor afferents and …

Over the past several decades capsaicin, a natural product of certain species of red pepper,
has been found to have a broad range of physiological effects in adult animals. Recent …