The coagulation and complement systems are central mediators of innate immune defense
and aide the peri-and intravascular elimination of invading microorganisms in a process …

The complement and coagulation cascades interact at multiple levels in thrombosis and
inflammatory diseases. In venous thrombosis, complement factor 3 (C3) is crucial for platelet …

The complement system is a component of innate immunity that preceded adaptive immunity
during evolution, and comprises a cascade of cysteine proteases similar to the organization …

Expanding evidence indicates multiple interactions between the hemostatic system and
innate immunity, and the coagulation and complement cascades. Here we show in a tissue …

Complement and coagulation are evolutionarily related proteolytic cascades in the blood
that are critical for effecting an appropriate innate response to injury that limits bleeding and …

The convergence between complement and the clotting system extends far beyond the
chemical nature of the complement and coagulation components, both of which form …

The coagulation and complement systems are ancestrally related enzymatic cascades of the
blood. Although their primary purposes have diverged over the past few hundred million …

Throughout evolution, organisms have developed means to contain wounds by
simultaneously limiting bleeding and eliminating pathogens and damaged host cells via the …

The complement system, originally classified as part of innate immunity, is a tightly self-
regulated system consisting of liquid phase, cell surface, and intracellular proteins. In the …

Coagulation and innate immunity are linked evolutionary processes that orchestrate the host
defence against invading pathogens and injury. The complement system is integral to innate …