Recent studies have demonstrated that delivery of genes to the inner ear can achieve a
variety of effects ranging from support of auditory neuron survival to protection and …

Mammalian inner ear harbors diverse cell types that are essential for hearing and balance.
Adenovirus is one of the major vectors to deliver genes into the inner ear for functional …

Murine models are ideal for studying cochlear gene transfer, as many hearing loss-related
mutations have been discovered and mapped within the mouse genome. However, because …

An important requirement for gene therapy in the inner ear is to achieve efficient gene
delivery without damaging residual inner ear function. This can be achieved by delivering a …

Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate
hearing and balance disorders. We previously established the benefits of Anc80L65 in …

Background Several genes are candidates for treating inner ear diseases. For clinical
applications, minimally invasive approaches to the inner ear are desirable along with …

There is keen interest to define gene therapies aimed at restoration of auditory and
vestibular function in the diseased or damaged mammalian inner ear. A persistent limitation …

Background Several groups demonstrated in animal experiments that gene transfer is a
feasible tool for inner ear intervention. Various approaches for inoculation of vectors have …

Factors influencing the damage to the inner ear can include the surgical approach used for
vector delivery, the volume of vector used, the buffer that the vector is suspended in as well …

Hearing loss, including genetic hearing loss, is one of the most common forms of sensory
deficits in humans with limited options of treatment. Adeno-associated virus (AAV)-mediated …