This article describes a study designed to assess the feasibility of using recombinant
adenovirus for delivering therapeutic peptides in vivo in the guinea pig middle ear cleft. A …

Cochlear gene therapy has made tremendous strides over the past 5 years. The first study
documenting successful restoration of congenital hearing loss using AAV-mediated gene …

Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary
deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even …

Several classes of viral vectors including adenovirus, adeno-associated virus, herpes
simplex virus, lentivirus and vaccinia virus have been reported to infect cells of the inner …

In a number of mouse models of hereditary deafness, therapeutic transgene delivery to the
cochlea and vestibular organs using adeno-associated viral vectors (AAVs) has shown …

Mice present an ideal model for inner ear gene therapy because their genome is being
rapidly sequenced, their generation time is relatively short, and they serve as a valuable …

Gene-based therapeutics are being developed as novel treatments for genetic hearing loss.
One roadblock to effective gene therapy is the identification of vectors which will safely …

Gene transfer is an exciting new tool in medical therapy and scientific investigation, but only
very recently has it begun to be developed in the auditory system. This paper describes in …

Gene transfer has been performed in a variety of organs. In the mammalian inner ear, viral
vectors have been used to introduce exogenous reporter genes via the scala tympani into …

Peripheral sensorineural hearing loss is a very common inner ear disorder affecting nearly
10% of the population. At present there is no cure for this disorder but gene therapy has …