iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors
ME Bogomiakova, EK Sekretova, KS Anufrieva… - Stem Cell Research & …, 2023 - Springer
Background Dozens of transplants generated from pluripotent stem cells are currently in
clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible …
clinical trials. The creation of patient-specific iPSCs makes personalized therapy possible …
Fit-for-all iPSC-derived cell therapies and their evaluation in humanized mice with NK cell immunity
C Flahou, T Morishima, H Takizawa… - Frontiers in …, 2021 - frontiersin.org
Human induced pluripotent stem cells (iPSCs) can be limitlessly expanded and
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …
Concise review: Immune recognition of induced pluripotent stem cells
Autologous‐induced pluripotent stem cells (iPSCs) may eventually be used in cell
replacement therapies to treat a wide range of diseases and have been touted as a solution …
replacement therapies to treat a wide range of diseases and have been touted as a solution …
Modulation of human allogeneic and syngeneic pluripotent stem cells and immunological implications for transplantation
SD Sackett, ME Brown, DM Tremmel, T Ellis… - Transplantation …, 2016 - Elsevier
Tissues derived from induced pluripotent stem cells (iPSCs) are a promising source of cells
for building various regenerative medicine therapies; from simply transplanting cells to …
for building various regenerative medicine therapies; from simply transplanting cells to …
The immunogenicity and immune tolerance of pluripotent stem cell derivatives
X Liu, W Li, X Fu, Y Xu - Frontiers in immunology, 2017 - frontiersin.org
Human embryonic stem cells (hESCs) can undergo unlimited self-renewal and differentiate
into all cell types in human body, and therefore hold great potential for cell therapy of …
into all cell types in human body, and therefore hold great potential for cell therapy of …
Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response
K Huang, PF Liu, X Li, SB Chen, LH Wang… - Science China Life …, 2014 - Springer
The breakthrough development of induced pluripotent stem cells (iPSCs) raises the prospect
of patient-specific treatment for many diseases through the replacement of affected cells …
of patient-specific treatment for many diseases through the replacement of affected cells …
New immunosuppressive cell therapy to prolong survival of induced pluripotent stem cell–derived allografts
H Sasaki, H Wada, M Baghdadi, H Tsuji… - …, 2015 - journals.lww.com
Background Induced pluripotent stem cell (iPSC) technology provides new opportunities in
regenerative medicine to generate grafts from donors for transplantation. However …
regenerative medicine to generate grafts from donors for transplantation. However …
Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings
K Masuda, H Kawamoto - Inflammation and Regeneration, 2021 - Springer
In the regenerative medicine field, allogenic transplantation of regenerated tissues has been
promoted because autologous transplantation setting is costly and time-consuming to …
promoted because autologous transplantation setting is costly and time-consuming to …
Inherent immunogenicity or lack thereof of pluripotent stem cells: implications for cell replacement therapy
A Chhabra - Frontiers in immunology, 2017 - frontiersin.org
Donor-specific induced pluripotent stem cells (iPSCs) offer opportunities for personalized
cell replacement therapeutic approaches due to their unlimited self-renewal potential and …
cell replacement therapeutic approaches due to their unlimited self-renewal potential and …
Brief report: immune microenvironment determines the immunogenicity of induced pluripotent stem cell derivatives
D Todorova, J Kim, S Hamzeinejad, J He, Y Xu - Stem Cells, 2016 - academic.oup.com
The breakthrough of induced pluripotent stem cells (iPSCs) has raised the possibility that
patient-specific iPSCs can provide autologous cells for cell therapy without the concern for …
patient-specific iPSCs can provide autologous cells for cell therapy without the concern for …