Extracellular vesicles induce mesenchymal transition and therapeutic resistance in glioblastomas through NF‐κB/STAT3 signaling

MW Schweiger, M Li, A Giovanazzi… - Advanced …, 2020 - Wiley Online Library
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal
treatment, long‐term survival remains uncommon. GBM can be roughly divided into three …

Current insights on extracellular vesicle-mediated glioblastoma progression: Implications in drug resistance and epithelial-mesenchymal transition

S Mukherjee, PP Pillai - Biochimica et Biophysica Acta (BBA)-General …, 2022 - Elsevier
Background Glioblastoma multiforme (GBM) is one of the most fatal tumors of the central
nervous system with high rate of disease progression, diagnosis, prognosis and low survival …

Extracellular vesicles as modulators of tumor microenvironment and disease progression in glioma

A Mondal, D Kumari Singh, S Panda, A Shiras - Frontiers in oncology, 2017 - frontiersin.org
Diffuse gliomas are lethal tumors of the central nervous system (CNS) characterized by
infiltrative growth, aggressive nature, and therapeutic resistance. The recent 2016 WHO …

Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype

S Oushy, JE Hellwinkel, M Wang… - … of the Royal …, 2018 - royalsocietypublishing.org
Glioblastoma multiforme (GBM) is a devastating tumour with abysmal prognoses. We
desperately need novel approaches to understand GBM biology and therapeutic …

Role of tumor-derived extracellular vesicles in glioblastoma

Y Chen, Y Jin, N Wu - Cells, 2021 - mdpi.com
Glioblastoma (GBM) is the most common primary central nervous system tumor and one of
the most lethal cancers worldwide, with morbidity of 5.26 per 100,000 population per year …

Extracellular vesicles in glioblastoma tumor microenvironment

A Yekula, A Yekula, K Muralidharan, K Kang… - Frontiers in …, 2020 - frontiersin.org
Glioblastomas (GBM) are highly aggressive primary brain tumors. Complex and dynamic
tumor microenvironment (TME) plays a crucial role in the sustained growth, proliferation, and …

Extracellular vesicles derived from glioblastoma promote proliferation and migration of neural progenitor cells via PI3K-Akt pathway

J Pan, S Sheng, L Ye, X Xu, Y Ma, X Feng, L Qiu… - Cell Communication and …, 2022 - Springer
Background Glioblastomas are lethal brain tumors under the current combinatorial
therapeutic strategy that includes surgery, chemo-and radio-therapies. Extensive changes in …

Glioblastoma extracellular vesicles induce the tumour-promoting transformation of neural stem cells

J Wang, J Liu, G Sun, H Meng, J Wang, Y Guan, Y Yin… - Cancer Letters, 2019 - Elsevier
Recurrent glioblastomas are frequently found near subventricular zone (SVZ) areas of the
brain where neural stem cells (NSCs) reside, and glioblastoma-derived extracellular …

Glioblastoma‐derived extracellular vesicles modify the phenotype of monocytic cells

J de Vrij, SLN Maas, KMC Kwappenberg… - … journal of cancer, 2015 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most common primary brain tumor and is without
exception lethal. GBMs modify the immune system, which contributes to the aggressive …

Microglial extracellular vesicles as modulators of brain microenvironment in glioma

M Catalano, C Serpe, C Limatola - International Journal of Molecular …, 2022 - mdpi.com
Microglial cells represent the resident immune elements of the central nervous system,
where they exert constant monitoring and contribute to preserving neuronal activity and …