A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …

A MUTATION at codon 717 of the β-amyloid precursor protein gene has been found to
cosegregate with familial Alzheimer's disease in a single family1. This mutation has been …

Mutations at codon 717 in exon 17 of the β–amyloid precursor protein (APP) gene have
previously been shown to segregate with early onset Alzheimer's disease in some families …

The gene coding for the amyloid protein, a component of neuritic plaques found in brain
tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and …

Amyloid β-protein (AP) is a peptide of relative molecular mass (M r) 42,000 found in the
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …

Following reports of mutations of codon 717 in exon 17 of the amyloid precursor protein
(APP) gene in early–onset familial Alzheimer's disease, we screened exon 17 for new …

THE accumulation in brain of senile plaques containing β-amyloid protein (Aβ) is a defining
feature of Alzheimer's disease1–3. The amyloid precursor protein (APP) 4 from which Aβ is …

Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary
tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's …

Several families with an early–onset form of familial Alzheimer's disease have been found to
harbour mutations at a specific codon (717) of the gene for the β–amyloid precursor protein …

Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …