Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
A Goate, MC Chartier-Harlin, M Mullan, J Brown… - Nature, 1991 - nature.com
A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …
chromosome 21 (ref. 1), close to the amyloid precursor protein (APP) gene2–5 …
Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene
MC Chartier-Harlin, F Crawford, H Houlden, A Warren… - Nature, 1991 - nature.com
A MUTATION at codon 717 of the β-amyloid precursor protein gene has been found to
cosegregate with familial Alzheimer's disease in a single family1. This mutation has been …
cosegregate with familial Alzheimer's disease in a single family1. This mutation has been …
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid
M Mullan, F Crawford, K Axelman, H Houlden, L Lilius… - Nature …, 1992 - nature.com
Mutations at codon 717 in exon 17 of the β–amyloid precursor protein (APP) gene have
previously been shown to segregate with early onset Alzheimer's disease in some families …
previously been shown to segregate with early onset Alzheimer's disease in some families …
Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families
CV Broeckhoven, AM Genthe, A Vandenberghe… - Nature, 1987 - nature.com
The gene coding for the amyloid protein, a component of neuritic plaques found in brain
tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and …
tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and …
The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene
RE Tanzi, PHS George-Hyslop, JL Haines, RJ Polinsky… - Nature, 1987 - nature.com
Amyloid β-protein (AP) is a peptide of relative molecular mass (M r) 42,000 found in the
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …
Mutation in codon 713 of the β amyloid precursor protein gene presenting with schizophrenia
CT Jones, S Morris, CM Yates, A Moffoot, C Sharpe… - Nature …, 1992 - nature.com
Following reports of mutations of codon 717 in exon 17 of the amyloid precursor protein
(APP) gene in early–onset familial Alzheimer's disease, we screened exon 17 for new …
(APP) gene in early–onset familial Alzheimer's disease, we screened exon 17 for new …
Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide
P Seubert, T Oltersdorf, MG Lee, R Barbour… - Nature, 1993 - nature.com
THE accumulation in brain of senile plaques containing β-amyloid protein (Aβ) is a defining
feature of Alzheimer's disease1–3. The amyloid precursor protein (APP) 4 from which Aβ is …
feature of Alzheimer's disease1–3. The amyloid precursor protein (APP) 4 from which Aβ is …
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
RE Tanzi, AI McClatchey, ED Lamperti… - Nature, 1988 - nature.com
Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary
tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's …
tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's …
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene
Several families with an early–onset form of familial Alzheimer's disease have been found to
harbour mutations at a specific codon (717) of the gene for the β–amyloid precursor protein …
harbour mutations at a specific codon (717) of the gene for the β–amyloid precursor protein …
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
R Sherrington, EI Rogaev, Y Liang, EA Rogaeva… - Nature, 1995 - nature.com
Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …
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