Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
M Vitiello, A Zullo, L Servillo, FP Mancini… - Ageing research …, 2017 - Elsevier
Abstract Sirtuin 6 (SIRT6) is a member of the sirtuin family NAD+-dependent deacetylases
with multiple roles in controlling organism homeostasis, lifespan, and diseases. Due to its …
with multiple roles in controlling organism homeostasis, lifespan, and diseases. Due to its …
[HTML][HTML] SIRT6 in senescence and aging-related cardiovascular diseases
X Li, L Liu, T Li, M Liu, Y Wang, H Ma, N Mu… - Frontiers in cell and …, 2021 - frontiersin.org
SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases
and has established diverse roles in aging, metabolism and disease. Its function is similar to …
and has established diverse roles in aging, metabolism and disease. Its function is similar to …
[HTML][HTML] SIRT6 in aging, metabolism, inflammation and cardiovascular diseases
Z Guo, P Li, J Ge, H Li - Aging and disease, 2022 - ncbi.nlm.nih.gov
As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …
Emerging roles of SIRT6 in human diseases and its modulators
The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
SIRT6: novel mechanisms and links to aging and disease
SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …
[HTML][HTML] SIRT1 and SIRT6: The role in aging-related diseases
Y You, W Liang - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2023 - Elsevier
Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …
The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease
JP Etchegaray, L Zhong… - Current topics in …, 2013 - ingentaconnect.com
SIRT6 is one of the seven members of the NAD-dependent family of sirtuins mammals. The
pleotropic identity of SIRT6 is manifested into several catalytic activities such as …
pleotropic identity of SIRT6 is manifested into several catalytic activities such as …
[HTML][HTML] SIRT7 in the aging process
FA Lagunas-Rangel - Cellular and Molecular Life Sciences, 2022 - Springer
Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …
over time. This has been associated with a number of features termed hallmarks of aging …
SIRT7: the seventh key to unlocking the mystery of aging
Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …
continuously exposed to a variety of exogenous and endogenous stresses, which engender …
[HTML][HTML] The role of mammalian Sirtuin 6 in cardiovascular diseases and diabetes mellitus
K Wu, Y Wang, R Liu, H Wang, T Rui - Frontiers in Physiology, 2023 - frontiersin.org
Cardiovascular diseases are severe diseases posing threat to human health because of
their high morbidity and mortality worldwide. The incidence of diabetes mellitus is also …
their high morbidity and mortality worldwide. The incidence of diabetes mellitus is also …