Forty-eight million Americans smoke because of addiction to nicotine, and prevention of
smoking initiation and new methods for aiding in smoking cessation are some of the most …

Despite the known adverse health effects associated with tobacco use, over 45 million
adults in the United States smoke. Cigarette smoking is the major etiologic factor associated …

Nicotine and its derivatives, by binding to nicotinic acetylcholine receptors (nAChR) on
bronchial epithelial cells, can regulate cellular proliferation and apoptosis via activating the …

The respiratory epithelium expresses the cholinergic system including nicotinic receptors
(nAChRs). It was reported that normal human bronchial epithelial cells (BEC), which are the …

Rationale: Studies strongly suggest that the nicotinic acetylcholine receptors for nicotine
(nAChRs) play a significant role in lung cancer predisposition and natural history. The …

Objectives Nicotine and its associated nicotinic acetylcholine receptors (nAChRs) are
believed to be involved in the progression of lung carcinomas. This study aimed at …

Summary nAChRs participate in the predisposition for preneoplastic lesions and the further
emergence of lung carcinomas. More studies are needed to determine the influence of gene …

Prenatal nicotine exposure impairs normal lung development and leads to diminished
pulmonary function after birth. Previous work from our laboratory has demonstrated that …

Cigarette smoking is associated with increased risk for all histologic types of lung cancer, but
why the strength of this association is stronger for squamous cell carcinoma than …

The genotoxic effects of tobacco carcinogens have long been recognized, the contribution of
tobacco components to cancerogenesis by cell surface receptor signaling is relatively …