Abstract Background Tanshinone IIA (Tan), the main active component of Salvia miltiorrhiza,
has been demonstrated to have antioxidant activity. Acetaminophen (APAP), a widely used …

Abstract Tanshinone IIA (Tan IIA), an active component in S. miltiorrhiza, has been reported
to have excellent antioxidant and detoxifying activity. Here, we prove that Tan IIA attenuates …

Acetaminophen (APAP) is one of the most frequently prescribed analgesic and anti-pyretic
drugs. However, APAP-induced hepatotoxicity is a major cause of acute liver failure globally …

Severe acetaminophen (APAP)‐induced hepatic damage is the second most common
cause for hepatic transplantation. Clinically, hepatic damage caused by APAP is treated …

Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to
overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) …

The vast majority of drug-induced liver injury is mainly attributed to acetaminophen (APAP)
overdose. Salvianolic acid A (Sal A), a powerful water-soluble compound obtained from …

Acetaminophen (APAP) is used drugs worldwide for treating pain and fever. However, APAP
overdose is the principal cause of acute liver failure in Western countries. Salvianolic acid B …

Background Limonin, a bioactive compound from citrus plants, exerts antioxidant activities,
however its therapeutic potential in acetaminophen (APAP)-induced hepatotoxicity remains …

Summary Acetaminophen (N-acetyl-p-aminophenol, APAP) overdose causes hepatotoxicity,
even liver failure, and oxidative stress plays pivotal role in its pathogenesis. Nicotinic acid …

Acetaminophen (APAP)-induced hepatotoxicity is the main cause of drug-induced liver
injury. This study investigated the protection of baicalin and its aglycone baicalein against …