Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
A genome-wide, whole brain approach to investigate genetic effects on neuroimaging
phenotypes for identifying quantitative trait loci is described. The Alzheimer's Disease …
phenotypes for identifying quantitative trait loci is described. The Alzheimer's Disease …
Genetic variation and neuroimaging measures in Alzheimer disease
A Biffi, CD Anderson, RS Desikan… - Archives of …, 2010 - jamanetwork.com
Objective To investigate whether genome-wide association study (GWAS)–validated and
GWAS-promising candidate loci influence magnetic resonance imaging measures and …
GWAS-promising candidate loci influence magnetic resonance imaging measures and …
Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate the
investigation of genetic influences on disease onset and trajectory as reflected in structural …
investigation of genetic influences on disease onset and trajectory as reflected in structural …
Genetic study of multimodal imaging Alzheimer's disease progression score implicates novel loci
Identifying genetic risk factors underpinning different aspects of Alzheimer's disease has the
potential to provide important insights into pathogenesis. Moving away from simple case …
potential to provide important insights into pathogenesis. Moving away from simple case …
Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease
In a genome-wide association study of structural brain degeneration, we mapped the 3D
profile of temporal lobe volume differences in 742 brain MRI scans of Alzheimer's disease …
profile of temporal lobe volume differences in 742 brain MRI scans of Alzheimer's disease …
Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects
Imaging traits provide a powerful and biologically relevant substrate to examine the
influence of genetics on the brain. Interest in genome-wide, brain-wide search for influential …
influence of genetics on the brain. Interest in genome-wide, brain-wide search for influential …
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers
Abstract The Genetics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI),
formally established in 2009, aims to provide resources and facilitate research related to …
formally established in 2009, aims to provide resources and facilitate research related to …
Voxelwise genome-wide association study (vGWAS)
The structure of the human brain is highly heritable, and is thought to be influenced by many
common genetic variants, many of which are currently unknown. Recent advances in …
common genetic variants, many of which are currently unknown. Recent advances in …
A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort
The underlying genetic etiology of late onset Alzheimer's disease (LOAD) remains largely
unknown, likely due to its polygenic architecture and a lack of sophisticated analytic …
unknown, likely due to its polygenic architecture and a lack of sophisticated analytic …
[HTML][HTML] Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans
Introduction Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …