As the number of elderly individuals rises, Alzheimer's disease (AD), marked by amyloid-β
deposition, neurofibrillary tangle formation, and low-level neuroinflammation, is expected to …

The interaction between CD40 and its cognate ligand, CD40 ligand, is a primary regulator of
the peripheral immune response, including modulation of T lymphocyte activation, B …

Increasing evidence supports a role of the CD40 receptor–CD40 ligand (CD40–CD40L)
interaction in the pathogenesis of Alzheimer's disease (AD). It has previously been shown …

Chronic neuroinflammatory processes including glial activation may play a role in the
pathogenesis of Alzheimer's disease (AD). The immune and inflammatory mediator CD40 …

We have previously shown that transgenic mice carrying a mutant human APP but deficient
in CD40L, display a decrease in astrocytosis and microgliosis associated with a lower …

Abstract Some 15–20% of the population over the age of 65 years suffer from dementia,
currently one of the leading causes of death behind cardiovascular diseases, cancer and …

We have shown that interaction of CD40 with CD40L enables microglial activation in
response to amyloid-β peptide (Aβ), which is associated with Alzheimer's disease (AD)-like …

CD40 is a member of the tumor necrosis factor receptor super-family and has been
suggested to play a role in the metabolism of β-amyloid (Aβ) in Alzheimer's disease (AD) …

It has been suggested that cerebrovascular factors contribute to Alzheimer's disease.
Soluble CD40 ligand (sCD40L) is directly involved in the development of vascular damage …

Although deposition of amyloid β‐peptide (Aβ) as Aβ plaques involves activation of
microglia‐mediated inflammatory responses, activated microglia ultimately fail to clear Aβ …