Key pathways to prevent posttraumatic arthritis for future molecule-based therapy
S Chubinskaya, MA Wimmer - Cartilage, 2013 - journals.sagepub.com
Joint injuries are common, especially among young adults aged 18 to 44 years. They are
accompanied by a cascade of events that increase the risk of posttraumatic osteoarthritis …
accompanied by a cascade of events that increase the risk of posttraumatic osteoarthritis …
Understanding articular cartilage injury and potential treatments
J Borrelli Jr, SA Olson, C Godbout… - … of orthopaedic trauma, 2019 - journals.lww.com
The goals of all orthopaedic surgeons treating articular cartilage injuries have been
anatomic reduction and stable fixation of the articular cartilage surface with restoration of …
anatomic reduction and stable fixation of the articular cartilage surface with restoration of …
Post-traumatic arthritis: definitions and burden of disease
JA Buckwalter, DT Felson - Post-traumatic arthritis: pathogenesis …, 2015 - Springer
Osteoarthritis, as distinguished from arthritis secondary to inflammatory or neurologic
disorders, is the most common form of joint disease and is one of the leading causes of …
disorders, is the most common form of joint disease and is one of the leading causes of …
Pathomechanisms of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment
J Riegger, RE Brenner - International journal of molecular sciences, 2020 - mdpi.com
Traumatic injuries of the knee joint result in a wide variety of pathomechanisms, which
contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These …
contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These …
Post-traumatic osteoarthritis: a review of pathogenic mechanisms and novel targets for mitigation
Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury and accounts for
12% of all osteoarthritis. These injuries, often of the lower extremity joints, occur due to …
12% of all osteoarthritis. These injuries, often of the lower extremity joints, occur due to …
Articular cartilage injury and potential remedies
S Chubinskaya, D Haudenschild… - … of orthopaedic trauma, 2015 - journals.lww.com
Osteoarthritis affects millions of people worldwide, is associated with joint stiffness and pain,
and often causes significant disability and loss of productivity. Osteoarthritis is believed to …
and often causes significant disability and loss of productivity. Osteoarthritis is believed to …
Overview: state of the art and future prospectives for cartilage repair
Articular cartilage degeneration, for example, resulting from joint injury and trauma, has
remained a major clinical challenge as cartilage does not have self-healing capability, and …
remained a major clinical challenge as cartilage does not have self-healing capability, and …
[HTML][HTML] A high-throughput model of post-traumatic osteoarthritis using engineered cartilage tissue analogs
B Mohanraj, GR Meloni, RL Mauck… - Osteoarthritis and cartilage, 2014 - Elsevier
Objective A number of in vitro models of post-traumatic osteoarthritis (PTOA) have been
developed to study the effect of mechanical overload on the processes that regulate …
developed to study the effect of mechanical overload on the processes that regulate …
[HTML][HTML] Pathogenetic mechanisms of posttraumatic osteoarthritis: opportunities for early intervention
WC Kramer, KJ Hendricks, J Wang - International journal of clinical …, 2011 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is characterized by joint pain and stiffness with radiographic evidence of
joint space narrowing, osteophytes, and subchondral bone sclerosis. Posttraumatic OA …
joint space narrowing, osteophytes, and subchondral bone sclerosis. Posttraumatic OA …
Articular cartilage repair: current needs, methods and research directions
D Correa, SA Lietman - Seminars in cell & developmental biology, 2017 - Elsevier
Articular cartilage is a highly specialized tissue whose remarkable properties of
deformability, resistance to mechanical loading, and low-friction gliding are essential to joint …
deformability, resistance to mechanical loading, and low-friction gliding are essential to joint …