Pembrolizumab (Anti-PD-1) Immunotherapy in Malignant Pleural Mesothelioma: A Systematic Review of the Current Literature

RM Ali, FH Kakamad, HO Abdullah, SH Abdulla… - Barw Medical …, 2023 - barw.krd
Introduction Malignant pleural mesothelioma is an infrequent and aggressive type of cancer
that is difficult to treat, and standard therapies have shown limited effectiveness. There have …

Clinical safety and activity of pembrolizumab in patients with malignant pleural mesothelioma (KEYNOTE-028): preliminary results from a non-randomised, open-label …

EW Alley, J Lopez, A Santoro, A Morosky… - The Lancet …, 2017 - thelancet.com
Background Malignant pleural mesothelioma is a highly aggressive cancer with poor
prognosis and few treatment options following progression on platinum-containing …

Immunotherapy in malignant pleural mesothelioma

CJ De Gooijer, FJ Borm, A Scherpereel… - Frontiers in …, 2020 - frontiersin.org
The only registered systemic treatment for malignant pleural mesothelioma (MPM) is
platinum based chemotherapy combined with pemetrexed, with or without bevacizumab …

Advances in immunotherapy of malignant pleural mesothelioma

D Liao, Y Yu, Q Mei, Z Wang, X Li, Y Jia… - OncoTargets and …, 2021 - Taylor & Francis
Malignant pleural mesothelioma (MPM) represents the uncommon cancer originating from
pleural mesothelial cells, which is associated with dismal prognostic outcome. According to …

[HTML][HTML] Pembrolizumab as palliative immunotherapy in malignant pleural mesothelioma

Y Metaxas, G Rivalland, LA Mauti, D Klingbiel… - Journal of Thoracic …, 2018 - Elsevier
Introduction There is no approved second-line treatment for malignant pleural mesothelioma
(MPM). On the basis of promising early results, pembrolizumab was used off-label in …

Current State-of-the-Art Therapy for Malignant Pleural Mesothelioma and Future Options Centered on Immunotherapy

S Cedres, A Valdivia, P Iranzo, A Callejo, N Pardo… - Cancers, 2023 - mdpi.com
Simple Summary Advances in malignant pleural mesothelioma research have led to the
approval of first-line immunotherapies and the development of numerous trials of new first …

Abstract CT103: Clinical safety and efficacy of pembrolizumab (MK-3475) in patients with malignant pleural mesothelioma: Preliminary results from KEYNOTE-028

EW Alley, LR Molife, A Santoro, K Beckey, S Yuan… - Cancer research, 2015 - AACR
Background: The programmed death receptor 1 (PD-1) pathway is implicated in evasion of
the antitumor immune response. Pembrolizumab is a potent, highly selective humanized …

Management of advanced pleural mesothelioma—at the crossroads

AK Nowak, A Jackson, C Sidhu - JCO Oncology Practice, 2022 - ascopubs.org
The management of pleural mesothelioma has changed with the demonstration that first-line
checkpoint blockade therapy improves survival. This review covers issues of relevance to …

[HTML][HTML] OA13. 03 long-term overall survival for patients with malignant pleural mesothelioma on pembrolizumab enrolled in KEYNOTE-028

E Alley, J Lopez, A Santoro, A Morosky, S Saraf… - Journal of Thoracic …, 2017 - jto.org
Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with poor
prognosis and limited treatment options after progression on platinum-containing …

The role of immunotherapy in the treatment of malignant pleural mesothelioma

S Banerji, DE Meyers, C Harlos, DE Dawe - Current Oncology, 2021 - mdpi.com
Malignant pleural mesothelioma is a rare and aggressive malignancy arising from
mesothelial cells that line the serous membranes of the body. Cytotoxic chemotherapy has …