Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of
metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine …

Background: Metabolic reprogramming of tumours is a hallmark of cancer. Among the
changes in the metabolic network of cancer cells, glutaminolysis is a key reaction altered in …

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …

Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to
provide energy, biosynthetic precursors and redox requirements to allow the massive …

Many cancer cells exhibit an altered metabolic phenotype, in which glutamine consumption
is upregulated relative to healthy cells. This metabolic reprogramming often depends upon …

Simple Summary Glutaminase GLS2 is an enzyme that metabolizes glutamine, one of the
main sources of energy and building blocks in tumor cells. In some types of cancer, this …

Cancer cells exhibit an altered metabolic phenotype, consuming higher levels of the amino
acid glutamine. This metabolic reprogramming depends on increased mitochondrial …

The targeting of glutamine metabolism specifically via pharmacological inhibition of
glutaminase 1 (GLS1) has been translated into clinical trials as a novel therapy for several …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Highlights•Inhibition of glutamine metabolism is an important mechanism in cancer
control.•Novel drugs offer a mechanism by which the key metabolic enzyme glutaminase …