The role of dopamine in motivation for food in humans: implications for obesity

GJ Wang, ND Volkow, JS Fowler - Expert opinion on therapeutic …, 2002 - Taylor & Francis
Obesity is a major public health problem. The increasing number of obese individuals in the
US adds urgency to the efforts to understand the mechanisms underlying pathological …

Imaging of brain dopamine pathways: implications for understanding obesity

GJ Wang, ND Volkow, PK Thanos… - Journal of addiction …, 2009 - journals.lww.com
Obesity is typically associated with abnormal eating behaviors. Brain imaging studies in
humans implicate the involvement of dopamine (DA)-modulated circuits in pathologic eating …

Striatal dopamine D2-like receptor correlation patterns with human obesity and opportunistic eating behavior

J Guo, WK Simmons, P Herscovitch, A Martin… - Molecular …, 2014 - nature.com
The obesity epidemic is believed to be driven by a food environment that promotes
consumption of inexpensive, convenient, high-calorie, palatable foods. Individual …

[HTML][HTML] Dopamine signaling in food addiction: role of dopamine D2 receptors

JH Baik - BMB reports, 2013 - ncbi.nlm.nih.gov
Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA signaling in mesolimbic neurotransmission are …

The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies

KA van Galen, KW Ter Horst, J Booij, SE la Fleur… - Metabolism, 2018 - Elsevier
Obesity results from an imbalance between energy intake and expenditure, and many
studies have aimed to determine why obese individuals continue to (over) consume food …

Mesolimbic dopamine and its neuromodulators in obesity and binge eating

L Naef, KA Pitman, SL Borgland - CNS spectrums, 2015 - cambridge.org
Obesity has reached epidemic prevalence, and much research has focused on homeostatic
and nonhomeostatic mechanisms underlying overconsumption of food. Mesocorticolimbic …

“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect

ND Volkow, GJ Wang, JS Fowler, J Logan, M Jayne… - Synapse, 2002 - Wiley Online Library
The drive for food is one of the most powerful of human and animal behaviors. Dopamine, a
neurotransmitter involved with motivation and reward, its believed to regulate food intake in …

Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors

ND Volkow, GJ Wang, F Telang, JS Fowler, PK Thanos… - Neuroimage, 2008 - Elsevier
Dopamine's role in inhibitory control is well recognized and its disruption may contribute to
behavioral disorders of discontrol such as obesity. However, the mechanism by which …

Dopamine D2/3 receptor availability and amphetamine-induced dopamine release in obesity

E van de Giessen, F Celik… - Journal of …, 2014 - journals.sagepub.com
Introduction: The neurotransmitter dopamine is important in the regulation of food intake. It is
hypothesised that obese people experience less reward from food due to lower striatal …

Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review

GJ Wang, ND Volkow, PK Thanos… - Journal of addictive …, 2004 - Taylor & Francis
Overeating in obese individuals shares similarities with the loss of control and compulsive
drug taking behavior observed in drug-addicted subjects. The mechanism of these …