[HTML][HTML] Effect of imipramine on memory, adult neurogenesis, neuroinflammation, and mitochondrial biogenesis in a rat model of alzheimer's disease

AJ Hasanabadi, E Beirami, M Kamaei… - Experimental …, 2024 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive decline and memory loss. Imipramine, a tricyclic antidepressant, has potent anti …

Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: possible contribution of MAPKs and insulin …

P Javadpour, S Askari, FS Rashidi, L Dargahi… - Behavioural Brain …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common age-related neurodegenerative disease,
associated with several pathophysiological complaints. Impaired insulin signaling in the …

Imipramine, in part through tumor necrosis factor α inhibition, prevents cognitive decline and β-amyloid accumulation in a mouse model of Alzheimer's disease

F Chavant, J Deguil, S Pain, I Ingrand, S Milin… - … of Pharmacology and …, 2010 - ASPET
Alzheimer's disease (AD), the most common form of dementia in the older people, is a
multifactoral pathology, characterized by cognitive deficits, increase in cerebral deposition of …

Imipramine, in part through TNF-α inhibition, prevents cognitive decline and Aβ accumulation in a mouse model of Alzheimer's disease

F Chavant, J Deguil, S Pain, I Ingrand, S Milin… - … of Pharmacology and …, 2009 - ASPET
Alzheimer9s disease (AD), the most common form of dementia in the elderly, is a
multifactoral pathology, characterized by cognitive deficits, increase in cerebral deposition of …

Naringin ameliorates memory deficits in experimental paradigm of Alzheimer's disease by attenuating mitochondrial dysfunction

AK Sachdeva, A Kuhad, K Chopra - Pharmacology Biochemistry and …, 2014 - Elsevier
Rationale Mitochondrial dysfunction has been well documented in age related disorders like
Alzheimer's disease. Alterations in mitochondrial membrane potential lead to neuronal …

Effects of the drug combination memantine and melatonin on impaired memory and brain neuronal deficits in an amyloid-predominant mouse model of Alzheimer's …

M Jürgenson, T Zharkovskaja… - Journal of Pharmacy …, 2019 - academic.oup.com
Objectives Alzheimer's disease (AD) is a neurodegenerative disorder with no cure. Limited
treatment options available today do not offer solutions to slow or stop any of the suspected …

Indomethacin attenuates neuroinflammation and memory impairment in an STZ-induced model of Alzheimer's like disease

A Karkhah, M Saadi, F Pourabdolhossein… - …, 2021 - Taylor & Francis
Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) exposure might be considerably
associated with a decreased risk of Alzheimer's disease (AD). Therefore, we conducted an …

Mitotherapy restores hippocampal mitochondrial function and cognitive impairment in aged male rats subjected to chronic mild stress

G Javani, S Babri, F Farajdokht, A Ghaffari-Nasab… - Biogerontology, 2023 - Springer
This study aimed to determine the effects of mitotherapy on learning and memory and
hippocampal kynurenine (Kyn) pathway, mitochondria function, and dendritic arborization …

[HTML][HTML] Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer's disease model

MK Andrade, LC Souza, EM Azevedo, EL Bail… - IBRO Neuroscience …, 2023 - Elsevier
Melatonin is a hormone secreted by the pineal gland, it can be associated with circadian
rhythms, aging and neuroprotection. Melatonin levels are decreased in sporadic Alzheimer's …

Piperine restores streptozotocin-induced cognitive impairments: Insights into oxidative balance in cerebrospinal fluid and hippocampus

M Khalili-Fomeshi, MG Azizi, MR Esmaeili… - Behavioural Brain …, 2018 - Elsevier
Piperine has been shown to have antioxidant activity and a cognitive-enhancing effect
following long-term oral administration. In a comparative study of memantine, the current …