Many genes differentially expressed in brain tissue from human alcoholics and animals that
have consumed large amounts of alcohol are components of the innate immune toll-like …

Although there are sex differences in the effects of alcohol on immune responses, it is
unclear if sex differences in immune response can influence drinking behavior. Activation of …

Background Molecular and behavioral studies support a role for innate immune
proinflammatory pathways in mediating the effects of alcohol. Increased levels of Toll‐like …

There is growing evidence that immune signalling may be involved in both the causes and
consequences of alcohol abuse. Toll‐like receptor (TLR) expression is increased by alcohol …

Toll-like receptor 4 (TLR4) is a critical component of innate immune signaling and has been
implicated in alcohol responses in preclinical and clinical models. Members of the …

Overactivation of neuroimmune signaling has been linked to excessive ethanol
consumption. Toll-like receptors (TLRs) are a major component of innate immune signaling …

Previous studies showed that mice with genetic predisposition for high alcohol consumption
as well as human alcoholics show changes in brain expression of genes related to immune …

Background Growing evidence suggests that neuroimmune signaling via Toll‐like receptors
(TLR s) alters brain circuitry related to alcohol use disorders. Both ethanol (EtOH) exposure …

Ethanol suppresses innate resistance to a variety of microbes, and findings of studies from
both our laboratory and other laboratories indicate suppression of responses is mediated …

Toll-like receptor (TLR) signaling may play an important role in the neuroimmune system's
involvement in the development and maintenance of alcohol use disorder (AUD). In the …