Even though the retinoblastoma gene is one of the best-studied tumor suppressor genes,
little is known about its functional role. Like all tumor suppressor gene products, the …

The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor
types. Mice lacking pRb have been produced as models of human disease, but have a …

The nuclear phosphoprotein encoded by the retinoblastoma gene (pRB) appears to play a
central role in control of cell division and differentiation. It is generally accepted that pRB is …

The retinoblastoma (RB) gene encodes a nuclear phosphoprotein of 928 amino acids
(pRB). Thus far, much effort in RB research has been focused on both the viral oncoprotein …

The product of the retinoblastoma tumor suppressor gene (pRb) and p107 share a high
degree of structural homology in the pocket region, which is thought to play a primary role in …

The cellular protein p107 shares many structural and biochemical features with the
retinoblastoma gene product, pRB. We have isolated a full-length cDNA for human p107 …

Genetic evidence from retinoblastoma patients and experiments describing the mechanism
of cellular transformation by the DNA tumor viruses have defined a central role for the …

Inactivation of the retinoblastoma susceptibility (RB) gene plays a role in the pathogenesis of
a variety of human malignancies. Recently, it has become feasible to study RB expression in …

The retinoblastoma gene (Rb) was the first tumor suppressor gene to be cloned [Dryja et al.,
1986; Friend et al., 1986; Lee et al., 1987], and, as a consequence, has been studied …