Hypoxia modulates the differentiation potential of stem cells of the apical papilla

J Vanacker, A Viswanath, P De Berdt, A Everard… - Journal of …, 2014 - Elsevier
Introduction Stem cells from the apical papilla (SCAP) are a population of mesenchymal
stem cells likely involved in regenerative endodontic procedures and have potential use as …

Vascular endothelial growth factor and/or nerve growth factor treatment induces expression of dentinogenic, neuronal, and healing markers in stem cells of the apical …

Z Shen, H Tsao, S LaRue, R Liu, TC Kirkpatrick… - Journal of …, 2021 - Elsevier
Introduction The goal of regenerative endodontic procedures is to preserve and stimulate
stem cells from the apical papilla (SCAPs) to develop the pulp-dentin complex using various …

Characterization of a stem cell of apical papilla cell line: effect of passage on cellular phenotype

NB Ruparel, JFA De Almeida, MA Henry… - Journal of …, 2013 - Elsevier
INTRODUCTION: Stem cells of the apical papilla (SCAP) have been identified as an
important population of mesenchymal stem cells (MSCs) in regenerative endodontics …

Coculture of stem cells from apical papilla and human umbilical vein endothelial cell under hypoxia increases the formation of three-dimensional vessel-like structures …

C Yuan, P Wang, L Zhu, WL Dissanayaka… - … Engineering Part A, 2015 - liebertpub.com
The success of bioengineered dental pulp depends on two principles,(1) whether the
transplanted tissue can develop its own vascular endothelial tubule network and (2) whether …

Survival of the apical papilla and its resident stem cells in a case of advanced pulpal necrosis and apical periodontitis

V Chrepa, B Pitcher, MA Henry, A Diogenes - Journal of endodontics, 2017 - Elsevier
Introduction Apical papilla represents a source of an enriched mesenchymal stem cell
(MSC) population (stem cells of the apical papilla [SCAPs]) that modulates root development …

Hypoxia induces DPSC differentiation versus a neurogenic phenotype by the paracrine mechanism

S Delle Monache, F Pulcini, F Santilli, S Martellucci… - Biomedicines, 2022 - mdpi.com
As previously described by several authors, dental pulp stem cells (DPSCs), when
adequately stimulated, may acquire a neuronal-like phenotype acting as a favorable source …

Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges

Q Liu, Y Gao, J He - Biomedicines, 2023 - mdpi.com
Dental diseases occurring on young permanent teeth usually lead to the premature arrest of
tooth root development. Sustained tooth root elongation is necessary to achieve the goal of …

Effects of lipopolysaccharide on the proliferation and osteogenic differentiation of stem cells from the apical papilla

V Lertchirakarn, P Aguilar - Journal of Endodontics, 2017 - Elsevier
Introduction Stem cells from the apical papilla (SCAPs) were suggested as the stem cell
source in regenerative endodontic procedures. However, bone and/or cementum-like …

Long‐term exposure to pro‐inflammatory cytokines inhibits the osteogenic/dentinogenic differentiation of stem cells from the apical papilla

C Liu, H Xiong, K Chen, Y Huang… - International …, 2016 - Wiley Online Library
Aim To investigate the in vitro effects of TNF‐α and IL‐1β on the osteogenic/dentinogenic
differentiation of stem cells from the apical papilla (SCAP). Methodology SCAP s treated with …

Molecular biological comparison of dental pulp-and apical papilla-derived stem cells

M Smeda, KM Galler, M Woelflick, A Rosendahl… - International Journal of …, 2022 - mdpi.com
Both the dental pulp and the apical papilla represent a promising source of mesenchymal
stem cells for regenerative endodontic protocols. The aim of this study was to outline …