Modeling thyroid cancer in the mouse

XG Zhu, SY Cheng - Hormone and metabolic research, 2009 - thieme-connect.com
Thyroid carcinomas, the most common endocrine tumors in humans, have an increasing
incidence in the US and worldwide. There are four major types of thyroid cancers: papillary …

Genetic alterations in thyroid cancer: the role of mouse models

KAB Knostman, SM Jhiang… - Veterinary pathology, 2007 - journals.sagepub.com
Thyroid carcinomas are the most common endocrine neoplasms in humans, with a globally
increasing incidence. Thyroid follicular cells and neuroendocrine (parafollicular) C cells are …

Mouse models of thyroid cancer: A 2015 update

LS Kirschner, Z Qamri, S Kari, A Ashtekar - Molecular and Cellular …, 2016 - Elsevier
Thyroid cancer is the most common endocrine neoplasm, and its rate is rising at an alarming
pace. Thus, there is a compelling need to develop in vivo models which will not only enable …

[HTML][HTML] Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates

HR Choi, K Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Although the overall prognosis of differentiated thyroid cancer (DTC), the most common
endocrine malignancy, is favorable, a subset of patients exhibits aggressive features …

Alterations in genomic profiles during tumor progression in a mouse model of follicular thyroid carcinoma

H Ying, H Suzuki, H Furumoto, R Walker… - …, 2003 - academic.oup.com
The molecular genetics underlying thyroid carcinogenesis is not well understood. We have
recently created a mutant mouse by targeting a mutation (PV) into the thyroid hormone …

Mouse models of papillary thyroid carcinoma—Short review

D Rusinek, J Krajewska, M Jarząb - Endokrynologia Polska, 2016 - journals.viamedica.pl
Thyroid carcinoma (TC) is the most common endocrine malignancy, and its frequency is still
rising. Papillary thyroid carcinoma (PTC) accounts for 80% of all TCs and usually is related …

[HTML][HTML] Mouse models of follicular and papillary thyroid cancer progression

MA Russo, VGA Arciuch, A Di Cristofano - Frontiers in Endocrinology, 2012 - frontiersin.org
A significant number of well-differentiated thyroid cancers progress or recur, becoming
resistant to current therapeutic options. Mouse models recapitulating the genetic and …

Lessons from mouse models of thyroid cancer

CS Kim, X Zhu - Thyroid, 2009 - liebertpub.com
Background: Thyroid cancer is the most common endocrine tumor and is increasing in
incidence. The aim of this study was to review mouse models of differentiated thyroid cancer …

[HTML][HTML] Preclinical models of follicular cell-derived thyroid cancer: an overview from cancer cell lines to mouse models

MJ Jeon, BR Haugen - Endocrinology and Metabolism, 2022 - synapse.koreamed.org
The overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive
disease and distant metastases with limited responses to systemic therapies. Thus, relevant …

[HTML][HTML] Development of novel follicular thyroid cancer models which progress to poorly differentiated and anaplastic thyroid cancer

CO Caperton, LA Jolly, N Massoll, AJ Bauer, AT Franco - Cancers, 2021 - mdpi.com
Simple Summary Advancements in thyroid cancer are dependent on the availability of
experimental models allowing for investigation in the laboratory setting. Here, we detail the …