DNA methylation plays a crucial role in the regulation of gene expression and chromatin
organization within normal eukaryotic cells. In cancer, however, global patterns of DNA …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

DNA methylation is one among the major grounds of cancer progression which is
characterized by the addition of a methyl group to the promoter region of the gene thereby …

DNA methylation is one of the best-known epigenetic modifications in mammals. The
alteration of DNA methylation patterns has been found to be related to many diseases …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

There is compelling evidence to support the importance of DNA methylation alterations in
cancer development. Both losses and gains of DNA methylation are observed, thought to …

The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …

DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …