Background Natural killer (NK) cells have efficient intrinsic recognition capabilities toward
abnormal cells. This fact makes them particularly attractive as safe effector cells for cancer …

Chimeric antigen receptors (CARs) provide a powerful strategy to direct and enhance anti-
tumor activity of immune effector cells. While most studies have evaluated CAR-expression …

Background aims Traditionally, natural killer (NK) cells are sourced from the peripheral
blood of donors―a laborious and highly donor-specific process. Processes for generating …

Cancer has been well established as a highly morbid disease state both in the United States
and worldwide, with cancers such as glioblastoma (GBM), the most aggressive brain tumor …

Background Natural killer (NK) cells are innate immune cells that play a key role in in tumor
immune surveillance. Recent advances allow for the derivation of immune cells, including …

Natural killer (NK) cells are potent anti-tumor effectors that play an important role in innate
and adaptive immunity. Despite recent clinical advances in the therapeutic use of NK cells …

Natural killer (NK) cells are unique from other immune cells in that they can rapidly kill
multiple neighboring cells without the need for antigenic pre-sensitization once the cells …

Clinical success of chimeric antigen receptor (CAR) T cell immunotherapy requires the
engineering of autologous T cells, which limits the broader implementation of CAR cell …

Background Glioblastoma multiforme (GBM) is a primary brain tumor with a high mortality
rate and median survival of~ 14 months. Although progress has been made in the …

Select subsets of immune effector cells have the greatest propensity to mediate antitumor
responses. However, procuring these subsets is challenging, and cell-based …