An increasing body of research indicates that stroma surrounding cancer cells plays an
important role in the development and subsequent behavior of the tumor. Studies using a …

The importance of stromal cells and the factors that they express during cancer initiation and
progression has been highlighted by recent literature. The cellular components of the stroma …

During tumorigenesis, reciprocal changes in stromal fibroblasts and tumor cells induce
changes to the neoplastic microenvironmental landscape. In stromagenesis, both the …

Although the stroma within carcinogenic lesions is known to be supportive and responsive to
tumors, new data increasingly show that the stroma also has a more active, oncogenic role …

Publisher Summary This chapter describes various modes of interaction between malignant
cells and stroma. Malignant cells are shown to produce various lytic enzymes, which attack …

Extensive research has been conducted over several decades understanding the genetic
changes that occur in normal cells to promote them towards a transformed state. However, it …

The role of tumor stroma in progression to malignancy has become the subject of intense
experimental and clinical interest. The stromal compartment of organs is composed of all the …

For decades, pathologists have recognized that the stroma surrounding tumors is in many
cases altered with obvious changes in the cellular composition and the extracellular matrix …

Recent advances in tumor biology have identified the stroma as an important regulator of
carcinogenesis and potentially a valuable therapeutic target. While however the fact that by …

Maintenance of epithelial tissues needs the stroma. When the epithelium changes, the
stroma inevitably follows. In cancer, changes in the stroma drive invasion and metastasis …