Multiple sclerosis (MS) predisposition is thought to be influenced by a complex, yet unclear
interaction of genetic and environmental factors. Studying ethnically selected populations …

Several lines of evidence indicate a genetic contribution to multiple sclerosis (MS) both in
terms of predisposition to the disease and of immunological mechanisms which are known …

Background: A wealth of single-nucleotide polymorphisms (SNPs) responsible for multiple
sclerosis (MS) susceptibility have been identified; however, they explain only a fraction of …

Multiple sclerosis (MS) is a chronic disease of the central nervous system affecting young
adults and thus representing a major burden also for their families and communities. The …

Objectives‐We studied the in vitro production of variably MS‐related cytokines from
Sardinian MS and healthy donors bearing the two “Sardinian” MS‐associated HLA‐DR …

HLA-DRB1*15 association with multiple sclerosis is confirmed in a multigenerational Italian family
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The prevalence of multiple sclerosis in Sardinia is significantly higher than in neighbouring
Mediterranean countries, suggesting that the isolated growth of the population has …

Background: Recent studies identified> 100 non-HLA (human leukocyte antigen) multiple
sclerosis (MS) susceptibility variants in Northern European populations, but their role in …

Human leukocyte antigen (HLA), a system involved in immune response to foreign antigens
and in autoimmunity, has been strongly implicated in multiple sclerosis (MS). Prior research …

In diseases with unpredictably long latent period, such as multiple sclerosis (MS), cluster
studies, and the analysis of disease distribution by gender and age of onset, can provide …