The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
LB Gano, AJ Donato, HM Pasha… - American Journal …, 2014 - journals.physiology.org
Reductions in arterial SIRT1 expression and activity with aging are linked to vascular
endothelial dysfunction. We tested the hypothesis that the specific SIRT1 activator SRT1720 …
endothelial dysfunction. We tested the hypothesis that the specific SIRT1 activator SRT1720 …
SIRT1 in endothelial cells as a novel target for the prevention of early vascular aging
As one of the main risk factors for cardiovascular diseases, ageing plays an important role in
the alterations of vascular structure and function. Early vascular ageing refers to a condition …
the alterations of vascular structure and function. Early vascular ageing refers to a condition …
[HTML][HTML] SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/-mice
S Stein, N Schäfer, A Breitenstein, C Besler… - Aging (Albany …, 2010 - ncbi.nlm.nih.gov
Excessive production of reactive oxygen species (ROS) contributes to progression of
atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory …
atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory …
The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response
Y xi Chen, M Zhang, Y Cai, Q Zhao, W Dai - Biochemical and biophysical …, 2015 - Elsevier
Activation of the silent mating type information regulation 2 homolog 1 (SIRT1) has been
shown consistent antiinflammatory function. However, little information is available on the …
shown consistent antiinflammatory function. However, little information is available on the …
Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle …
Aims Aged arteries are characterized by attenuated vasodilator and enhanced
vasoconstrictor responses, which contribute to the development of diseases such as arterial …
vasoconstrictor responses, which contribute to the development of diseases such as arterial …
SIRT1‐mediated ERβ suppression in the endothelium contributes to vascular aging
D Kong, Y Zhan, Z Liu, T Ding, M Li, H Yu, L Zhang… - Aging …, 2016 - Wiley Online Library
SIRT 1 has many important molecular functions in aging, and the estrogen receptors (ER s)
have a vasculoprotective effect, although the detailed mechanism for the roles of SIRT 1 and …
have a vasculoprotective effect, although the detailed mechanism for the roles of SIRT 1 and …
SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging
MJ Zarzuelo, R López-Sepúlveda, M Sánchez… - Biochemical …, 2013 - Elsevier
Vascular aging is characterized by up-regulation of NADPH oxidase, oxidative stress and
endothelial dysfunction. Previous studies demonstrate that the activity of the evolutionarily …
endothelial dysfunction. Previous studies demonstrate that the activity of the evolutionarily …
Endothelial SIRT1 as a target for the prevention of arterial aging: promises and challenges
MK Begum, D Konja, S Singh… - Journal of …, 2021 - journals.lww.com
SIRT1, a member of the sirtuin family of longevity regulators, possesses potent activities
preventing vascular aging. The expression and function of SIRT1 in endothelial cells are …
preventing vascular aging. The expression and function of SIRT1 in endothelial cells are …
Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress
K Yang, S Velagapudi, A Akhmedov… - Cardiovascular …, 2023 - academic.oup.com
Aims Enhancing SIRT1 activity exerts beneficial cardiovascular effects. In diabetes, plasma
SIRT1 levels are reduced. We aimed to investigate the therapeutic potential of chronic …
SIRT1 levels are reduced. We aimed to investigate the therapeutic potential of chronic …
[HTML][HTML] The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis
M Kitada, Y Ogura, D Koya - Aging (Albany NY), 2016 - ncbi.nlm.nih.gov
Cardiovascular disease (CVD) due to atherosclerosis is the main cause of death in both the
elderly and patients with metabolic diseases, including diabetes. Aging processes contribute …
elderly and patients with metabolic diseases, including diabetes. Aging processes contribute …
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