Reductions in arterial SIRT1 expression and activity with aging are linked to vascular
endothelial dysfunction. We tested the hypothesis that the specific SIRT1 activator SRT1720 …

As one of the main risk factors for cardiovascular diseases, ageing plays an important role in
the alterations of vascular structure and function. Early vascular ageing refers to a condition …

Excessive production of reactive oxygen species (ROS) contributes to progression of
atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory …

Activation of the silent mating type information regulation 2 homolog 1 (SIRT1) has been
shown consistent antiinflammatory function. However, little information is available on the …

Aims Aged arteries are characterized by attenuated vasodilator and enhanced
vasoconstrictor responses, which contribute to the development of diseases such as arterial …

SIRT 1 has many important molecular functions in aging, and the estrogen receptors (ER s)
have a vasculoprotective effect, although the detailed mechanism for the roles of SIRT 1 and …

Vascular aging is characterized by up-regulation of NADPH oxidase, oxidative stress and
endothelial dysfunction. Previous studies demonstrate that the activity of the evolutionarily …

SIRT1, a member of the sirtuin family of longevity regulators, possesses potent activities
preventing vascular aging. The expression and function of SIRT1 in endothelial cells are …

Aims Enhancing SIRT1 activity exerts beneficial cardiovascular effects. In diabetes, plasma
SIRT1 levels are reduced. We aimed to investigate the therapeutic potential of chronic …

Cardiovascular disease (CVD) due to atherosclerosis is the main cause of death in both the
elderly and patients with metabolic diseases, including diabetes. Aging processes contribute …