Histone Methyltransferase MLL1 Regulates MDR1 Transcription and Chemoresistance
H Huo, PG Magro, EC Pietsch, BB Patel, KW Scotto - Cancer research, 2010 - AACR
The multidrug resistance 1 gene (MDR1) encodes P-glycoprotein (Pgp), a member of the
ATP-binding cassette (ABC) transporter family that confers tumor drug resistance by actively …
ATP-binding cassette (ABC) transporter family that confers tumor drug resistance by actively …
Precipitous Release of Methyl-CpG Binding Protein 2 and Histone Deacetylase 1 from the Methylated Human Multidrug Resistance Gene (MDR1) on Activation
A El-Osta, P Kantharidis, JR Zalcberg… - Molecular and cellular …, 2002 - Taylor & Francis
Overexpression of the human multidrug resistance gene 1 (MDR1) is a negative prognostic
factor in leukemia. Despite intense efforts to characterize the gene at the molecular level …
factor in leukemia. Despite intense efforts to characterize the gene at the molecular level …
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs
EK Baker, RW Johnstone, JR Zalcberg, A El-Osta - Oncogene, 2005 - nature.com
The mechanism of action of chemotherapeutic drugs and their ability to induce multidrug
resistance (MDR) are of relevance to cancer treatment. Overexpression of P-glycoprotein …
resistance (MDR) are of relevance to cancer treatment. Overexpression of P-glycoprotein …
Regulation of MDR1 gene expression: emerging concepts
P Kantharidis, S El-Osta, M De Silva, G Lee… - Drug Resistance …, 2000 - Elsevier
Drug resistance genes, such as MDR1, involved in drug efflux, and their regulation have
been the subject of intense research efforts in the past 10 years. Many factors and cellular …
been the subject of intense research efforts in the past 10 years. Many factors and cellular …
MDR1 Gene Overexpression and Altered Degree of Methylation at the Promoter Region in Bladder Cancer during Chemotherapeutic Treatment
Y Tada, M Wada, K Kuroiwa, N Kinugawa, T Harada… - Clinical cancer …, 2000 - AACR
Overexpression of the multidrug resistance 1 (MDR1) gene is closely associated with the
clinical outcome of hematopoietic malignancies, but the alteration of its expression during …
clinical outcome of hematopoietic malignancies, but the alteration of its expression during …
Hypomethylation Status of CpG Sites at the Promoter Region and Overexpression of the Human MDR1 Gene in Acute Myeloid Leukemias
M Nakayama, M Wada, T Harada… - Blood, The Journal …, 1998 - ashpublications.org
Selection of human cells for resistance to vincristine or doxorubicin often induces
overexpression of the multidrug resistance 1 gene (MDR1), which encodes the cell surface …
overexpression of the multidrug resistance 1 gene (MDR1), which encodes the cell surface …
MDR1, Chemotherapy and chromatin remodeling
EK Baker, A El-Osta - Cancer biology & therapy, 2004 - Taylor & Francis
The development of multidrug resistance (MDR) in cancer can severely impede the efficacy
of chemotherapy treatment. P-glycoprotein (Pgp) overexpression, encoded by the MDR1 …
of chemotherapy treatment. P-glycoprotein (Pgp) overexpression, encoded by the MDR1 …
Association of 5′ CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in …
H Kusaba, M Nakayama, T Harada… - European journal of …, 1999 - Wiley Online Library
Selection of human cells for resistance to vincristine or doxorubicin often induces
overexpression of the multidrug resistance 1 gene (MDR1), which encodes the cell surface …
overexpression of the multidrug resistance 1 gene (MDR1), which encodes the cell surface …
Methylation analysis of the human multidrug resistance 1 gene in normal and leukemic hematopoietic cells
KB Fryxell, SB McGee, DK Simoneaux, CL Willman… - Leukemia, 1999 - nature.com
Expression of the human multidrug resistance 1 gene (MDR1), which encodes the P-
glycoprotein transmembrane efflux pump, has been associated with treatment failure of …
glycoprotein transmembrane efflux pump, has been associated with treatment failure of …
The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer
EK Baker, A El-Osta - Experimental cell research, 2003 - Elsevier
In recent years, the different classes of drugs and regimens used clinically have provided an
improvement in tumour management. However, treatment is often palliative for the majority …
improvement in tumour management. However, treatment is often palliative for the majority …