Traumatic handling of the tumor independent of pneumoperitoneum increases port site implantation rate of colon cancer in a murine model

SW Lee, J Southall, J Allendorf, M Bessler… - Surgical endoscopy, 1998 - Springer
Background: Reports of port site tumor recurrences after laparoscopic-assisted resection of
colon tumors have raised concerns about the safety of laparoscopic cancer surgery. Tumor …

Impact of laparoscopic colonic resection on tumour growth and spread in an experimental model

CN Gutt, V Riemer, ZG Kim, CA Jacobi… - Journal of British …, 1999 - academic.oup.com
Background The influence of surgical manipulation and carbon dioxide pneumoperitoneum
on intraperitoneal tumour growth and port-site metastasis during laparoscopic colon …

The effect of laparoscopy on the movement of tumor cells and metastasis to surgical wounds

G Mathew, DI Watson, T Ellis, N De Young, AM Rofe… - Surgical …, 1997 - Springer
Background: A variety of mechanisms have been proposed to explain tumor growth in port
sites following laparoscopic cancer surgery. We devised two experimental models to …

Conditioning of the abdominal cavity reduces tumor implantation in a laparoscopic mouse model

MM Binda, R Corona, F Amant, PR Koninckx - Surgery Today, 2014 - Springer
Purpose The addition of 4% O 2 and 10% N 2 O to the CO 2 pneumoperitoneum (PP),
together with slight cooling and humidification (conditioning), contributes to reducing …

Effect of carbon dioxide pneumoperitoneum and wound closure technique on port site tumor implantation in a rat model

JM Burns, BD Matthews, HS Pollinger… - Surgical Endoscopy and …, 2005 - Springer
Background The purpose of this study was to evaluate the effects of carbon dioxide (CO 2)
pneumoperitoneum and wound closure technique on port site tumor implantation. Methods …

Impact of pneumoperitoneum on trocar site implantation of colon cancer in hamster model

DB Jones, LW Guo, MK Reinhard… - Diseases of the colon …, 1995 - journals.lww.com
BACKGROUND: Numerous anecdotal reports have documented the spread of colon cancer
to trocar sites after laparoscopic-assisted colectomy. We hypothesized that the …

Intraperitoneal hypothermia during surgery enhances postoperative tumor growth

CC Nduka, M Puttick, P Coates, L Yong, D Peck… - Surgical …, 2002 - Springer
Background Recent work has shown that intraoperative hypothermia is a significant source
of surgical trauma, with wide-ranging physiological and immunological sequelae. The aim of …

A PROPOSED MODEL FOR THE MOVEMENT OF CELLS WITHIN THE |ABDOMINAL CAVITY DURING CO2 INSUFFLATION AND LAPAROSCOPY

WM Thomas, MC Eaton… - Australian and New …, 1996 - Wiley Online Library
Background: The application of laparoscopic‐assisted surgery to gastrointestinal
malignancy has lead to the recurrence of malignancy in wounds created during these …

The impact of laparoscopy with carbon dioxide versus helium on immunologic function and tumor growth in a rat model

CA Jacobi, F Wenger, R Sabat, T Volk, J Ordemann… - Digestive …, 1998 - karger.com
Background: The pathogenesis of port site recurrences after laparoscopic surgery for
malignant disease is still unknown. Whether different gases used to establish …

[PDF][PDF] Higher colon cancer tumor proliferative index and lower tumor cell death rate in mice undergoing laparotomy versus insufflation

SW Lee, N Gleason, I Blanco, ZK Asi… - Surgical …, 2002 - researchgate.net
Background: Our laboratory has previously shown that tumors are established more easily
and grow larger after laparotomy than after laparoscopy. To characterize these differences in …