DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

Cancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation,
but these two types of epigenetic abnormalities usually seem to affect different DNA …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

While specific genes are hypermethylated in the genome of cancer cells, overall
methylcytosine content is often decreased as a consequence of hypomethylation affecting …

Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

It is not surprising that cancer, a kind of derangement of development, hijacks DNA
methylation, which is necessary for normal mammalian embryogenesis. Both decreases and …

In contrast to earlier views that there was much compartmentalization of the types of
sequences subject to cancer-linked changes in DNA epigenetics, it is now clear that both …

Cytosine methylation is a heritable modification of DNA in mammalian cells, and has a
determinant impact on long-term gene repression and genome stability. Genomic …

DNA methylation is one of the best-known epigenetic modifications in mammals. The
alteration of DNA methylation patterns has been found to be related to many diseases …

The epigenome, which is comprised of chromatin and its associated proteins and the
patterns of covalent modification of DNA by methylation, sets up and maintains gene …