Self microemulsifying drug delivery system of lurasidone hydrochloride for enhanced oral bioavailability by lymphatic targeting: in vitro, Caco-2 cell line and in vivo …

MH Patel, KK Sawant - European Journal of Pharmaceutical Sciences, 2019 - Elsevier
The global aim of this research was to develop and evaluate self-microemulsifying drug
delivery system (SMEDDS) to improve oral bioavailability of Lurasidone Hydrochloride (LH) …

Oral absorption and lymphatic transport of baicalein following drug–phospholipid complex incorporation in self-microemulsifying drug delivery systems

H Liao, Y Gao, C Lian, Y Zhang, B Wang… - International journal …, 2019 - Taylor & Francis
Purpose The aims of this study were to prepare a baicalein self-microemulsion with
baicalein-phospholipid complex as the intermediate (BAPC-SMEDDS) and to compare its …

Formulation and characterization of lipid-based drug delivery system of raloxifene-microemulsion and self-microemulsifying drug delivery system

H Thakkar, J Nangesh, M Parmar… - Journal of Pharmacy and …, 2011 - journals.lww.com
Background: Raloxifene, a second-generation selective estrogen receptor modulator
(SERM) used to prevent osteoporosis in postmenopausal women is administered orally in …

Novel Drug Delivery Approach via Self-Microemulsifying Drug Delivery System for Enhancing Oral Bioavailability of Asenapine Maleate: Optimization, Characterization, Cell …

MH Patel, VP Mundada, KK Sawant - AAPS pharmscitech, 2019 - Springer
Asenapine maleate (AM)-loaded self-microemulsifying drug delivery system (AM-SMEDDS)
was prepared to increase its oral bioavailability. AM-SMEDDS was developed using Capryol …

Development and pharmacokinetic evaluation of industrially viable self-microemulsifying drug delivery systems (SMEDDS) for terbinafine

A Baheti, S Srivastava, D Sahoo… - Current drug …, 2016 - ingentaconnect.com
Objective: The aim of this study was to develop a formulation for lymphatic uptake with
enhanced solubility of antifungal drug, terbinafine by use of self-microemulsifying drug …

[HTML][HTML] Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems

K Jo, H Kim, P Khadka, T Jang, SJ Kim… - Asian Journal of …, 2020 - Elsevier
The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus
(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility …

Formulation and Evaluation of a Self-Microemulsifying Drug Delivery System of Raloxifene with Improved Solubility and Oral Bioavailability

MM Ansari, DK Vo, HI Choi, JS Ryu, Y Bae, NI Bukhari… - Pharmaceutics, 2023 - mdpi.com
Poor aqueous solubility and dissolution limit the oral bioavailability of Biopharmaceutics
Classification System (BCS) class II drugs. In this study, we aimed to improve the aqueous …

Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation

X Sha, J Wu, Y Chen, X Fang - International Journal of …, 2012 - Taylor & Francis
The objective of our investigation was to design a self-microemulsifying drug-delivery
system (SMEDDS) to improve the bioavailability of probucol. SMEDDS was composed of …

Self microemulsifying particles of loratadine for improved oral bioavailability: preparation, characterization and in vivo evaluation

KV Madhav, V Kishan - Journal of Pharmaceutical Investigation, 2018 - Springer
The objective was to study the phase behavior of different formulations, to identify the micro
emulsion area and to prepare solid SMEDDS particles (SSMED) of loratadine (LOR) for …

Dissolution evaluation in vitro and bioavailability in vivo of self-microemulsifying drug delivery systems for pH-sensitive drug loratadine

H Li, Y Tan, L Yang, L Gao, T Wang… - Journal of …, 2015 - Taylor & Francis
The aim of this study was to improve the oral absorption of loratadine, a pH-sensitive drug,
by self-microemulsifying drug delivery systems (SMEDDSs). The optimal SMEDDS was …