Prognostic impact of t (16; 21)(p11; q22) and t (16; 21)(q24; q22) in pediatric AML: a retrospective study by the I-BFM Study Group
S Noort, M Zimmermann, D Reinhardt… - Blood, The Journal …, 2018 - ashpublications.org
To study the prognostic relevance of rare genetic aberrations in acute myeloid leukemia
(AML), such as t (16; 21), international collaboration is required. Two different types of t (16; …
(AML), such as t (16; 21), international collaboration is required. Two different types of t (16; …
Cryptic chromosomal aberrations leading to an AML1/ETO rearrangement are frequently caused by small insertions
U Gamerdinger, A Teigler‐Schlegel… - Genes …, 2003 - Wiley Online Library
Abstract The translocation t (8; 21)(q22; q22), which results in the fusion of the AML1
(RUNX1) and ETO (CBFA2T1) genes, is a recurrent aberration in acute myeloid leukemia …
(RUNX1) and ETO (CBFA2T1) genes, is a recurrent aberration in acute myeloid leukemia …
CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype
Pediatric cytogenetically normal acute myeloid leukemia (CN-AML) is a heterogeneous
subgroup of myeloid clonal disorders that do not harbor known mutations. To investigate the …
subgroup of myeloid clonal disorders that do not harbor known mutations. To investigate the …
Epigenetic heterogeneity affects the risk of relapse in children with t(8;21)RUNX1-RUNX1T1-rearranged AML
Abstract The somatic translocation t (8; 21)(q22; q22)/RUNX1-RUNX1T1 is one of the most
frequent rearrangements found in children with standard-risk acute myeloid leukemia (AML) …
frequent rearrangements found in children with standard-risk acute myeloid leukemia (AML) …
Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3‐ITD status: a report from the Children's …
K Tarlock, TA Alonzo, PP Moraleda… - British journal of …, 2014 - Wiley Online Library
Acute myeloid leukaemia (AML) with t (6; 9)(p23; q34) is a rare subtype associated with
FLT3‐internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of …
FLT3‐internal tandem duplication (ITD) and poor outcomes. The clinical outcomes of …
Molecular characteristic of acute leukemias with t(16;21)/FUS-ERG
E Zerkalenkova, A Panfyorova, A Kazakova… - Annals of …, 2018 - Springer
Abstract T (16; 21)(p11; q22)/FUS-ERG is a rare but recurrent translocation in acute
leukemias and in some types of solid tumors. Due to multiple types of FUS-ERG transcripts …
leukemias and in some types of solid tumors. Due to multiple types of FUS-ERG transcripts …
[HTML][HTML] Molecular profiling defines distinct prognostic subgroups in childhood AML: a report from the French ELAM02 study group
A Marceau-Renaut, N Duployez, B Ducourneau… - …, 2018 - journals.lww.com
Despite major treatment improvements over the past decades, pediatric acute myeloid
leukemia (AML) is still a life-threatening malignancy with relapse rates up to 30% and …
leukemia (AML) is still a life-threatening malignancy with relapse rates up to 30% and …
High number of additional genetic lesions in acute myeloid leukemia with t (8; 21)/RUNX1-RUNX1T1: frequency and impact on clinical outcome
MT Krauth, C Eder, T Alpermann, U Bacher… - Leukemia, 2014 - nature.com
Abstract t (8; 21)/RUNX1-RUNX1T1-positive acute myeloid leukemia (AML) is prognostically
favorable; however, outcome is heterogeneous. We analyzed 139 patients with t (8; …
favorable; however, outcome is heterogeneous. We analyzed 139 patients with t (8; …
Incidence and prognostic impact of ASXL2 mutations in adult acute myeloid leukemia patients with t (8; 21)(q22; q22): a study of the German-Austrian AML Study …
Acute myeloid leukemia (AML) with t (8; 21)(q22; q22)/RUNX1/RUNX1T1 is categorized as a
distinct entity within the WHO category 'AML with recurrent genetic abnormalities'. 1 The …
distinct entity within the WHO category 'AML with recurrent genetic abnormalities'. 1 The …
AML with translocation t (8; 16)(p11; p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features
T Haferlach, A Kohlmann, HU Klein, C Ruckert… - Leukemia, 2009 - nature.com
Balanced chromosomal rearrangements define distinct entities in acute myeloid leukemia
(AML). Here, we present 13 AML cases with t (8; 16)(p11; p13) with observed low incidence …
(AML). Here, we present 13 AML cases with t (8; 16)(p11; p13) with observed low incidence …