Germinal centers (GCs) are specialized microenvironments formed after infection where
activated B cells can mutate their B‐cell receptors to undergo affinity maturation. A stringent …

Germinal center (GC) B cells undergo affinity selection, which depends on interactions with
CD4+ follicular helper T cells (TFH cells). We found that TFH cells progressed through …

Germinal centers (GC) constitute a specialized microenvironment essential for the formation
of memory B cells, B cell affinity maturation and isotype switching. Within the GC, the B cells …

Abstract Germinal center-B (GC-B) cells differentiate into memory B cells and plasma cells
(PC) through interaction with T cells and follicular dendritic cells (FDC). Activated T cell and …

Higher-or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC
recycling, respectively; however, how commitment to the plasma cell fate takes place is …

Germinal center (GC) B cells undergo complex interactions with follicular dendritic cells
(FDC) and T cells in the course of differentiation into memory B and plasma cells. To …

Humoral immunity requires interaction between specialized populations of B cells and CD4+
T cells, called follicular helper T cells (TFH cells), in the germinal center (GC) to produce …

Within the B-cell follicle of secondary lymphoid organs, germinal center (GC) reactions
produce high affinity antibody-secreting plasma cells (PCs) and memory B-cells necessary …

High-affinity class-switched Abs and memory B cells are products of the germinal center
(GC). The CD4+ T cell help required for the development and maintenance of the GC is …

Germinal centers (GC) are the main sites where antigen‐activated B‐cell clones expand and
undergo immunoglobulin gene hypermutation and selection. Iterations of this process will …