Clinical trials eligibility of patients with malignant pleural mesothelioma: use of novel therapies and outcomes
Introduction Studies of bevacizumab and pembrolizumab in the treatment of malignant
pleural mesothelioma suggest anticancer efficacy; clinical trial populations are not reflective …
pleural mesothelioma suggest anticancer efficacy; clinical trial populations are not reflective …
BEAT-meso: A randomized phase III study of bevacizumab (B) and standard chemotherapy (C) with or without atezolizumab (A), as first-line treatment (TX) for …
LBA8002 Background: The currently approved frontline TXs for PM are the combination of
ipilimumab/nivolumab or platinum plus pemetrexed. The addition of B to C has been shown …
ipilimumab/nivolumab or platinum plus pemetrexed. The addition of B to C has been shown …
OA04. 06 PEMbrolizumab Plus Lenvatinib In Second And Third Line Malignant Pleural MEsotheLiomA Patients: A Single Arm Phase II Study (PEMMELA)
LAH Douma, CJ De Gooijer, V Noort, F Lalezari… - Journal of Thoracic …, 2022 - jto.org
Methods PEMMELA was a prospective single-center, single-arm, open-label, investigator-
initiated phase 2 trial of pembrolizumab (200 mg once every three weeks intravenously) plus …
initiated phase 2 trial of pembrolizumab (200 mg once every three weeks intravenously) plus …
Pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in Canada, Italy, and France: a phase 3, open-label …
Background Pleural mesothelioma usually presents at an advanced, incurable stage.
Chemotherapy with platinum–pemetrexed is a standard treatment. We hypothesised that the …
Chemotherapy with platinum–pemetrexed is a standard treatment. We hypothesised that the …
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label …
G Zalcman, J Mazieres, J Margery, L Greillier… - The Lancet, 2016 - thelancet.com
Background Malignant pleural mesothelioma is an aggressive cancer with poor prognosis,
linked to occupational asbestos exposure. Vascular endothelial growth factor is a key …
linked to occupational asbestos exposure. Vascular endothelial growth factor is a key …
Comparison of 3 randomized clinical trials of frontline therapies for malignant pleural mesothelioma
Importance Some recently proposed frontline therapies for malignant pleural mesothelioma
(MPM) are very costly, yet their impact on quality of life and overall survival of these patients …
(MPM) are very costly, yet their impact on quality of life and overall survival of these patients …
[HTML][HTML] A real-world analysis of the use of systemic therapy in malignant pleural mesothelioma and the differential impacts on overall survival by practice pattern
Introduction Malignant pleural mesothelioma (MPM) is an aggressive malignancy that affects
older adults with frequent comorbidities, making real-world treatment decisions challenging …
older adults with frequent comorbidities, making real-world treatment decisions challenging …
[HTML][HTML] OA13. 03 long-term overall survival for patients with malignant pleural mesothelioma on pembrolizumab enrolled in KEYNOTE-028
E Alley, J Lopez, A Santoro, A Morosky, S Saraf… - Journal of Thoracic …, 2017 - jto.org
Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with poor
prognosis and limited treatment options after progression on platinum-containing …
prognosis and limited treatment options after progression on platinum-containing …
Current treatments for inoperable mesothelioma: indirect comparisons based on individual patient data reconstructed retrospectively from 4 trials
A Messori, S Trippoli - Journal of Chemotherapy, 2023 - Taylor & Francis
In inoperable pleural mesothelioma, pemetrexed+ cisplatin as first line is considered the
standard of care, but novel treatments have been recently proposed. Our objective was to …
standard of care, but novel treatments have been recently proposed. Our objective was to …
P2. 18-05 Impact of evolving treatment paradigms on survival outcomes in advanced pleural mesothelioma: a real-world analysis
FTH Wu, E Bhang, MK Sarvestani, CW Lee… - Journal of Thoracic …, 2023 - jto.org
Methods A retrospective analysis was conducted on all patients referred to BC Cancer who
(i) were diagnosed with pleural mesothelioma between January 2010 and December 2020 …
(i) were diagnosed with pleural mesothelioma between January 2010 and December 2020 …