The term epigenetics was coined in the context of developmental studies, but the meaning of
the term has evolved over time. Epigenetic modulators of gene expression are now known to …

Environmental toxicants such as toxic metals can alter epigenetic regulatory features such
as DNA methylation, histone modification, and non-coding RNA expression. Heavy metals …

The true understanding of epigenetics evolved over time as our knowledge on DNA
methylation and chromatin modifications and their effects on gene expression increased …

Although it is widely accepted that chronic exposure to arsenite, nickel, chromium and
cadmium increases cancer incidence in individuals, the molecular mechanisms underlying …

Abstract Purpose of the Review Exposure to essential and non-essential metals is
widespread. Metals exposure is linked to epigenetic, particularly DNA methylation …

Although carcinogenic metals have been known to disrupt a wide range of cellular
processes the precise mechanism by which they exert their carcinogenic effects is not …

Certain forms of the heavy metals arsenic and chromium are considered human
carcinogens, although they are believed to act through very different mechanisms …

Metals are common toxic environmental pollutants. Acute or chronic exposure to metal
pollutants causes severe adverse health effects in animals and humans, such as …

Prenatal exposure to the highly toxic and common pollutant cadmium has been associated
with adverse effects on child health and development. However, the underlying biological …

Exposure to toxic metals poses a serious human health hazard based on ubiquitous
environmental presence, the extent of exposure, and the toxicity and disease states …